公开(公告)号：US10709815B2

公开(公告)日：2020-07-14

申请号：US15800446

申请日：2017-11-01

Applicant: KENT STATE UNIVERSITY

Inventor： Elda Hegmann ,  Marianne E. Prévôt ,  Torsten Hegmann

IPC: A61L27/56 ,  C08G18/28 ,  A61L27/58 ,  A61K9/70 ,  A61L27/16 ,  A61L27/38 ,  A61L27/50 ,  A61L27/14 ,  A61L27/60 ,  C08J9/26 ,  C08G18/48 ,  C08G18/42

Abstract: Star block copolymers having 3 to 8 arms are formed as a 3D foam scaffold having tailor-made pore sizes that mimic an actual cell size of a specific animal and/or human tissue and/or organs. The pore sizes are made within the elastomeric foams via a salt leaching process wherein a salt of a specific particle size is blended within the star block copolymers and crosslinked as by polyisocyanate compounds. Water or other suitable solvent are utilized to dissolve and leach out the salt leaving an open pore system. Animal and/or human cells are then injected into the 3D elastomeric foam scaffold that contains pendant liquid crystals on the star block copolymer whereby with the aid of nutrients, cells are formed within the pore system that are viable for at least three months. The size of the pore is predetermined to produce a desired cultured cell having a desired size. The tissue and/or cells within the elastomeric scaffold can be applied to animal and/or human tissue and/or organs whereupon they grow and reconstruct the damaged, injured, diseased, etc., area and result in a healthy, repaired, and viable tissue or organ. The elastomeric liquid crystal containing foam scaffold will degrade naturally and/or also be consumed by the growing cells so that it no longer exists. In other words, a specific type of animal or human cell can be culturally produced having a predetermined average cell diameter that is substantially or essentially the same diameter of a natural cell.