公开(公告)号：US20240335396A1

公开(公告)日：2024-10-10

申请号：US18611735

申请日：2024-03-21

申请人： KIM DUNG THI DAO

发明人： KIM DUNG THI DAO ,  MINH HAI LUU

IPC分类号： A61K31/12 ,  A61K9/107 ,  A61K31/355 ,  A61K31/519 ,  A61K36/82 ,  A61K36/886 ,  A61K47/10 ,  A61K47/24 ,  A61K47/36 ,  A61P17/02

CPC分类号： A61K31/12 ,  A61K9/1075 ,  A61K31/355 ,  A61K31/519 ,  A61K36/82 ,  A61K36/886 ,  A61K47/10 ,  A61K47/24 ,  A61K47/36 ,  A61P17/02

摘要： The nano liquid composition containing curcumin have the ability to treating burns and increasing the effect of scar healing obtained by homogenously mixing a curcumin nano ingredient with a foundation mixture in a ratio of 1:1 by emulsifying equipment. The composition overcomes the disadvantages of curcumin, an organic compound with a broad spectrum of activities, including hard to dissolve in water, poor stability, and rapidly transformed. In addition, the composition of the present invention is used at a dose of 0.05-0.1 mL/cm 2 of skin, with a frequency of twice daily, had increased effect of scar healing in experimental doxorubicin-induced mouse models of skin ulceration, increased concentration of hydroxyprolin in skin, improved skin microstructure compared to control models after 21 days of application; and had no systemic toxicity after 21 days of application in the doxorubicin-induced skin ulcered mouse.