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公开(公告)号：US09889170B1
公开(公告)日：2018-02-13
申请号：US15287653
申请日：2016-10-06
申请人： KING SAUD UNIVERSITY
发明人： Manal Ahmed Gasmelseed Awad , Rabab Abd El Moneim Khalil El Dib , Awatif Ahmed Hendi , Shaza Mohamed Adel Al-Massarani , Khalid Mustafa Osman Ortashi
IPC分类号： A61K36/185 , A61K36/889 , A01N65/08 , A01N59/16 , A61K33/24 , A61K33/30 , A61K9/16 , C12P3/00 , C01G9/02 , B22F9/24 , B22F1/00
CPC分类号： A61K36/185 , A01N59/16 , A01N65/08 , A61K9/16 , A61K33/24 , A61K33/30 , B22F1/0044 , B22F9/24 , B22F2009/245 , B22F2301/255 , B22F2998/10 , C01G9/02 , C01P2004/16 , C01P2004/32 , C01P2004/62 , C01P2004/64 , C12P3/00
摘要： A method of preparing nanoparticles from desert date can include providing a metal salt solution comprising metal ions; providing desert date extract solution that comprises a reducing agent, and combining the metal ion solution and the desert date extract solution while stirring at a temperature in the range of 25° C. to 100° C. to produce metal or metal oxide nanoparticles. The metal nanoparticles can be gold nanoparticles. The metal oxide nanoparticles can be zinc oxide nanoparticles. The nanoparticles can be used to inhibit the growth or proliferation of a cancer cell and/or microorganisms.
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公开(公告)号：US10947266B2
公开(公告)日：2021-03-16
申请号：US16552670
申请日：2019-08-27
申请人： KING SAUD UNIVERSITY
发明人： Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Manal Ahmed Gasmelseed Awad , Ali Ali Hasan Elgamal
摘要： The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
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公开(公告)号：US10954264B2
公开(公告)日：2021-03-23
申请号：US16552351
申请日：2019-08-27
申请人： KING SAUD UNIVERSITY
发明人： Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Manal Ahmed Gasmelseed Awad , Ali Ali Hasan Elgamal
摘要： The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
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公开(公告)号：US09974750B1
公开(公告)日：2018-05-22
申请号：US15785277
申请日：2017-10-16
申请人： KING SAUD UNIVERSITY
发明人： Shaza Mohamed Adel Al-Massarani , Rabab Abd El Moneim Khalil El Dib , Ali Ali El-Gamal , Manal Ahmed Gasmelseed
摘要： Synthesis of ifflaionic acid nanoparticles includes dissolving a powder of ifflaionic acid in an alcohol solution to form a first solution, adding the first solution to an aqueous solution under ultrasonic conditions to produce a sonicated solution, stirring the sonicated solution for a duration of time to produce a mixture, and freeze-drying the mixture to provide the ifflaionic acid nanoparticles.
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公开(公告)号：US10278999B2
公开(公告)日：2019-05-07
申请号：US15826018
申请日：2017-11-29
申请人： KING SAUD UNIVERSITY
发明人： Ali Ali El-Gamal , Adnan Jathlan Al-Rehaily , Manal Ahmed Gasmelseed Awad , Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani
IPC分类号： A61K36/185
摘要： In one embodiment, synthesis of Nuxia oppositifolia nanoparticles includes providing a Nuxia oppositifolia powder; dissolving the powder in a first alcohol to provide a first alcohol extract; concentrating a filtrate from the first alcohol extract under reduced pressure to provide a dried alcohol extract; dissolving the dried alcohol extract in the first alcohol to provide a second alcohol extract; successively partitioning the second alcohol extract using n-hexane to provide an n-hexane extract; dissolving the n-hexane extract in a second alcohol and water to provide a first solution; and adding an acidic solution to the first solution to form a final solution including Nuxia oppositifolia nanoparticles.
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公开(公告)号：US10028988B1
公开(公告)日：2018-07-24
申请号：US15611768
申请日：2017-06-01
申请人： KING SAUD UNIVERSITY
发明人： Manal Ahmed Gasmelseed Awad , Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Ali Ali El-Gamal
IPC分类号： A61K36/185 , A61K9/14
CPC分类号： A61K36/185 , A61K9/14 , A61K9/141 , A61K2236/33 , A61K2236/51 , A61K2236/53
摘要： Synthesis of Nuxia oppositifolia nanoparticles includes providing an extract of Nuxia oppositifolia, dissolving the extract in alcohol to provide a mixture, adding water to the mixture to provide an aqueous solution, adding an acidic solution to the aqueous solution to form a final solution including Nuxia oppositifolia nanoparticles; and centrifuging the final solution to isolate the Nuxia oppositifolia nanoparticles.
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公开(公告)号：US10947265B2
公开(公告)日：2021-03-16
申请号：US16552496
申请日：2019-08-27
申请人： KING SAUD UNIVERSITY
发明人： Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Manal Ahmed Gasmelseed Awad , Ali Ali Hasan Elgamal
摘要： The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
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公开(公告)号：US10442833B1
公开(公告)日：2019-10-15
申请号：US16202046
申请日：2018-11-27
申请人： KING SAUD UNIVERSITY
发明人： Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Manal Ahmed Gasmelseed Awad , Ali Ali Hasan El Gamal
摘要： The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
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公开(公告)号：US10202415B1
公开(公告)日：2019-02-12
申请号：US15788181
申请日：2017-10-19
申请人： KING SAUD UNIVERSITY
发明人： Rabab Abd El Moneim Khalil El Dib , Shaza Mohamed Adel Al-Massarani , Manal Ahmed Gasmelseed Awad , Ali Ali El-Gamal
摘要： A method for synthesizing 3-oxolupenal nanoparticles including isolating 3-oxolupenal from a fraction of Nuxia oppositifolia plant, reducing the 3-oxolupenal to obtain a powder of 3-oxolupenal, dissolving the powder of 3-oxolupenal in methanol to form a first solution, adding the first solution to boiling water to form a second solution, sonicating the second solution, and freeze-drying after sonication to obtain the synthesized 3-oxolupenal nanoparticles. The synthesized 3-oxolupenal nanoparticles exhibited cytotoxic effects and antimicrobial effects.
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