公开(公告)号：US09493494B2

公开(公告)日：2016-11-15

申请号：US14473901

申请日：2014-08-29

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee ,  Young Chul Park ,  In Cheol Jeon ,  Jung Min Seo ,  Bo Ram Seo

IPC: C07F9/6584 ,  C07F9/6571

CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

Abstract: Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative.The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies.In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

Abstract translation: 此外，根据本发明的次膦氧化物衍生物的制备方法，可以通过使用在次膦酸衍生物和炔衍生物之间的分子内环状的简单的合成方法，在存在下制备具有高产率的各种次膦酰氧化物衍生物 的铑（Rh）催化剂或钌（Ru）催化剂和氧化剂。

公开(公告)号：US20150344506A1

公开(公告)日：2015-12-03

申请号：US14473901

申请日：2014-08-29

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee ,  Young Chul Park ,  In Cheol Jeon ,  Jung Min Seo ,  Bo Ram Seo

IPC: C07F9/6584 ,  C07F9/6571

CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

Abstract: Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative.The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies.In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

Abstract translation: 提供了一种新型的次膦酰氧化物衍生物及其制备方法，更具体地说，该次膦酰氧化物衍生物包括氧化磷腈氧化物衍生物和氮代膦酸氧化物衍生物。 本发明的次膦氧化物衍生物可以具有药理活性和生理活性，可以作为天然产物的基本框架使用，可用于新药的开发和各种医疗用品的合成。 此外，根据本发明的次膦氧化物衍生物的制备方法，可以通过使用在次膦酸衍生物和炔衍生物之间的分子内环状的简单的合成方法，在存在下制备具有高产率的各种次膦酰氧化物衍生物 的铑（Rh）催化剂或钌（Ru）催化剂和氧化剂。