公开(公告)号：US20180344805A1

公开(公告)日：2018-12-06

申请号：US15771692

申请日：2015-11-15

申请人： Agalimmune Limited (GB/GB) ,  Kode Biotech Limited (NZ/NZ)

发明人： Graham GRIFFITHS ,  Stephen SHAW ,  Nicolai Vladimirovich BOVIN ,  Alexander Borisovich TUZIKOV ,  Elena Yurievna KORCHAGINA ,  Stephen HENRY

IPC分类号： A61K38/14 ,  C07K9/00 ,  C07K14/00 ,  C07H15/04 ,  A61K31/7028 ,  A61K38/16 ,  A61K45/06 ,  A61P35/00

CPC分类号： C07H15/10 ,  A61K31/7032 ,  C07K9/001

摘要： The invention relates to novel glycolipid compounds and pharmaceutical compositions comprising said glycolipids and to processes for preparing said glycolipids. The invention also relates to said glycolipids for use in treating tumours and methods of treating tumours using said glycolipids.

公开(公告)号：US20230374076A1

公开(公告)日：2023-11-23

申请号：US18363810

申请日：2023-08-02

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Vladimirovich BOVIN ,  Stephen Micheal HENRY ,  Alexander Borisovich TUZIKOV

IPC分类号： C07K9/00 ,  A61K47/54 ,  A61K47/64 ,  C07K1/107 ,  C07K19/00

CPC分类号： C07K9/001 ,  A61K47/545 ,  A61K47/64 ,  A61K47/549 ,  C07K1/1077 ,  C07K19/00

摘要： The preparation of water dispersible ceramide conjugates and derivatives of sphingolipid analogues is described. The conjugates and analogues are prepared by reacting a succinimidyl carbonate of a β-Ala derivative with the primary amine of a functionalised spacer. Despite their dispersibility in water, the ceramide conjugates and derivatives of sphingolipid analogues spontaneously incorporate in to the plasma membranes of cells.