公开(公告)号：US20190310257A1

公开(公告)日：2019-10-10

申请号：US16446526

申请日：2019-06-19

Applicant: KONICA MINOLTA, INC.

Inventor： Katsuko YAMASHITA ,  Takatoshi KAYA ,  Youichi IDE ,  Tomonori KANEKO

IPC: G01N33/574 ,  G01N33/68

Abstract: A method of analyzing diagnostic information for estimating which of a benign prostate disease and prostate cancer is affecting a subject to be diagnosed combines two methods of analyzing diagnostic information. The first method includes measuring a concentration of a mucin-1 (Tn-MUC1), reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine->serine(threonine) residue, in a subject blood sample, comparing the measured value with a threshold value, and estimating that a disease affecting the subject is benign prostate disease when the measured value is greater than the threshold value. The second method includes measuring a concentration of a prostate-specific antigen (LacdiNAc-PSA), reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine B1-4 N-acetylglucosamine residue in the blood sample, comparing the measured value with a threshold value, and estimating that the disease affecting the subject is prostate cancer when the measured value of LacdiNAc-PSA is greater than the threshold value.

公开(公告)号：US20160313337A1

公开(公告)日：2016-10-27

申请号：US15108283

申请日：2013-12-27

Applicant: KONICA MINOLTA, INC.

Inventor： Katsuko YAMASHITA ,  Takatoshi KAYA ,  Youichi IDE ,  Tomonori KANEKO

IPC: G01N33/574

CPC classification number: G01N33/57434 ,  G01N33/6893 ,  G01N2333/42 ,  G01N2333/4725 ,  G01N2800/342

Abstract: A method of analyzing diagnostic information, the method including: measuring a concentration of a mucin-1 (Tn-MUC1), which is reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine→serine (threonine) residue, in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of Tn-MUC1 is greater than the threshold value.

Abstract translation: 一种分析诊断信息的方法，所述方法包括：测量与识别并结合N-乙酰基-D-半乳糖胺→丝氨酸（苏氨酸）残基的凝集素反应的粘蛋白-1（Tn-MUC1）的浓度 来自待诊断对象的血液样本; 将测量值与阈值进行比较; 并且当Tn-MUC1的浓度的测量值大于阈值时，估计影响待诊断对象的疾病不是前列腺癌而是良性前列腺疾病。

公开(公告)号：US20160305960A1

公开(公告)日：2016-10-20

申请号：US15108286

申请日：2013-12-27

Applicant: KONICA MINOLTA, INC.

Inventor： Katsuko YAMASHITA ,  Takatoshi KAYA ,  Youichi IDE ,  Tomonori KANEKO

IPC: G01N33/68 ,  G01N33/573

CPC classification number: G01N33/6893 ,  G01N33/573 ,  G01N33/57434 ,  G01N2333/4725 ,  G01N2333/705 ,  G01N2333/96455 ,  G01N2800/342

Abstract: A method of analyzing diagnostic information, the method including: measuring the concentration of all mucin-1s (total MUC1) in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of total MUC1 is greater than the threshold value.

Abstract translation: 一种分析诊断信息的方法，所述方法包括：测量源自待诊断对象的血液样品中所有粘蛋白-1（总MUC1）的浓度; 将测量值与阈值进行比较; 并且当总MUC1的浓度的测量值大于阈值时，估计影响待诊断对象的疾病不是前列腺癌而是良性前列腺疾病。