公开(公告)号：US11207043B2

公开(公告)日：2021-12-28

申请号：US16497026

申请日：2018-03-20

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen

IPC: A61B6/00 ,  G16H30/40 ,  G06T7/00 ,  G06T7/55

Abstract: The present invention relates to image processing devices and related methods. The image processing device (10) comprises a data input (11) for receiving spectral computed tomography volumetric image data organized in voxels. The image data comprises a contrast-enhanced volumetric image of a cardiac region in a subject's body and a baseline volumetric image of that cardiac region, e.g. a virtual non-contrast image, wherein the contrast-enhanced volumetric image conveys anatomical information regarding coronary artery anatomy of the subject. The device comprises a flow simulator (12) for generating, or receiving as input, a three-dimensional coronary tree model based on the volumetric image data and for simulating a coronary flow based on the three-dimensional coronary tree model. The device comprises a perfusion synthesis unit (13) for generating a perfusion image representative of a blood distribution in tissue at at least one instant in time taking at least the baseline volumetric image and said coronary flow simulation into account.

公开(公告)号：US12051202B2

公开(公告)日：2024-07-30

申请号：US16498730

申请日：2018-03-29

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen

IPC: G06T7/00 ,  G06T7/12 ,  G06T17/00 ,  G16H30/40 ,  G16H50/50

CPC classification number: G06T7/0014 ,  G06T7/12 ,  G06T17/005 ,  G16H30/40 ,  G16H50/50 ,  G06T2207/10081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06T2207/30104 ,  G06T2211/404

Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a biophysical simulator component (126) configured to determine a fractional flow reserve index. The system further includes a processor (120) configured to execute the biophysical simulator component (126) to determine the fractional flow reserve index with spectral volumetric image data. The system further includes a display configured to display the determine fractional flow reserve index.

公开(公告)号：US11602321B2

公开(公告)日：2023-03-14

申请号：US17041172

申请日：2019-03-22

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen

IPC: G06T7/00 ,  G06T15/08 ,  A61B6/00

Abstract: A system (300) includes a memory (324) configured to store an inflammation map generator module (328). The system further includes a processor (322) configured to: receive at least one of spectral projection data or spectral volumetric image data, decompose the at least one of spectral projection data or spectral volumetric image data using a two-basis decomposition to generate a set of vectors for each basis represented in the at least one of spectral projection data or spectral volumetric image data, compute a concentration of each basis within a voxel from the set of vectors for each basis, and determine a concentration of at least one of fat or inflammation within the voxel from the concentration of each basis. The system further includes a display configured to display the determined concentration of the at least one of fat or inflammation.

公开(公告)号：US11417034B2

公开(公告)日：2022-08-16

申请号：US16962261

申请日：2019-01-07

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Liran Goshen ,  Mordechay Pinchas Freiman

IPC: A61B6/00 ,  G06T11/00 ,  G16H30/40 ,  A61B6/03 ,  G06N3/08

Abstract: An imaging system (102) includes a radiation source (112) configured to emit X-ray radiation, a detector array (114) configured to detect X-ray radiation and generate a signal indicative thereof, an a reconstructor (116) configured to reconstruct the signal and generate non-spectral image data. The imaging system further includes a processor (124) configured to process the non-spectral image data using a deep learning regression algorithm to estimate spectral data from a group consisting of spectral basis components and a spectral image.

公开(公告)号：US11523744B2

公开(公告)日：2022-12-13

申请号：US16498578

申请日：2018-03-05

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen ,  Douglas B. McKnight

IPC: A61B5/029 ,  G16H50/50 ,  G16H30/40 ,  A61B5/02 ,  G06T7/00

Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a biophysical simulator component (126) configured to determine a fractional flow reserve value via simulation and a traffic light engine (128) configured to track a user-interaction with the computing system at one or more points of the simulation to determine the fractional flow reserve value. A processor (120) is configured to execute the biophysical simulator component to determine the fractional flow reserve value and configured to execute the traffic light engine to track the user-interaction with respect to determining the fractional flow reserve value and provide a warning in response to determining there is a potential incorrect interaction. A display is configured to display the warning requesting verification to proceed with the simulation from the point, wherein the simulation is resumed only in response to the processor receiving the requested verification.

公开(公告)号：US11039804B2

公开(公告)日：2021-06-22

申请号：US16331562

申请日：2017-09-15

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen ,  Hannes Nickisch

IPC: A61B6/00 ,  A61B5/02 ,  G16H50/50 ,  G16H30/40 ,  A61B5/026 ,  G06T7/00

Abstract: The present invention relates to an apparatus (26) and a method for determining a fractional flow reserve. For this purpose, a new personalized hyperemic boundary condition model is provided. The personalized hyperemic boundary condition model is used to condition a parametric model for a simulation of a blood flow in a coronary tree (34) of a human subject. As a basis for the personalized hyperemic boundary condition model, a predefined hyperemic boundary condition model is used, which represents empirical derived hyperemic boundary condition parameters. However, these empirical hyperemic boundary condition parameters are not specific for a human subject under examination. In order to achieve a specification of the respective predefined hyperemic boundary condition model, specific human subject features are derived from a volumetric image of the coronary tree of the human subject. These features are used to adjust the predefined hyperemic boundary condition model resulting in a personalized hyperemic boundary condition model. As an effect, a flow simulation using the parametric model conditioned by the personalized hyperemic boundary condition model. As an effect, a flow simulation using the parametric model conditioned by the personalized hyperemic boundary condition model improves the performance of flow simulation in order to determine an enhanced fractional flow reserve.

公开(公告)号：US10258303B2

公开(公告)日：2019-04-16

申请号：US15317158

申请日：2015-06-24

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Michael Grass ,  Yechiel Lamash ,  Liran Goshen ,  Holger Schmitt ,  Mordechay Pinchas Freiman ,  Hannes Nickisch ,  Sven Prevrhal

IPC: A61B5/04 ,  A61B6/00 ,  G16H50/50 ,  A61B5/02 ,  A61B6/03 ,  A61B6/06 ,  A61B5/029

Abstract: The invention relates to an apparatus for determining a fractional flow reserve (FFR) value of the coronary artery system of a living being (3). A fractional flow reserve value determination unit (13) determines the FFR value by using an FFR value determination algorithm that is adapted to determine the FFR value based on a boundary condition and a provided representation of the coronary artery system, wherein the boundary condition is specific for the living being and determined by a boundary condition determination unit (12). Since the boundary condition determination unit determines a boundary condition, which is specific for the living being, and since the fractional flow reserve value determination unit not only uses the provided representation of the coronary artery system, but also the living being specific boundary condition for determining the FFR value, the accuracy of the FFR value, which is non-invasively determined, can be improved.

公开(公告)号：US11633118B2

公开(公告)日：2023-04-25

申请号：US16498548

申请日：2018-06-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen

IPC: A61B5/026 ,  G06N20/00 ,  G06F30/27 ,  G06T5/50 ,  G06T7/00

Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a biophysical simulator (126) configured to determine a fractional flow reserve value. The system further includes a processor (120) configured to execute the biophysical simulator (126), which employs machine learning to determine the fractional flow reserve value with spectral volumetric image data. The system further includes a display configured to display the determine fractional flow reserve value.

公开(公告)号：US11361432B2

公开(公告)日：2022-06-14

申请号：US16632420

申请日：2018-07-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Mordechay Pinchas Freiman ,  Liran Goshen

IPC: G06T7/00 ,  A61B6/03 ,  A61B6/00 ,  G06T15/08

Abstract: The present invention relates to X-ray image data analysis of a part of a cardiovascular system of a patient in order to estimate a level of inflammation in the part of the cardiovascular system. X-ray image data is received, a segmented model of the part of the cardiovascular system is generated and predetermined features related to inflammation are extracted from the segmented model. The extracted features are used as input to an inflammation function for calculating inflammation values of which each represents a level of inflammation in the part of the cardiovascular system. The image data analysis can improve the estimation of inflammation. Furthermore, the inflammation values can be presented to a user together with suggestions for performing actions. This can for example enable a prediction of plaque development as well as future acute coronary syndrome events.

公开(公告)号：US11055845B2

公开(公告)日：2021-07-06

申请号：US16348282

申请日：2017-11-16

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Hannes Nickisch ,  Holger Schmitt ,  Sven Prevrhal ,  Mordechay Pinchas Freiman ,  Liran Goshen

IPC: G06T7/00 ,  G06T7/162 ,  G06T7/11 ,  G16H30/40 ,  A61B6/03 ,  A61B6/00 ,  G16H50/50

Abstract: A computing system (126) includes a computer readable storage medium (130) with computer executable instructions (128), including: a segmentation standardizer (120) configured to determine a standardized vascular tree from a segmented vascular tree segmented of volumetric image data and a predetermined set of pruning rules (206), and a biophysical simulator (122) configured to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a processor (124) configured to execute the segmentation standardizer to determine the standardized vascular tree from the segmented vascular tree segmented of volumetric image data and the predetermined set of pruning rules, and configured to execute the biophysical simulator to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a display configured to display at least one of the standardized vascular tree and a result of the biophysical simulation.