公开(公告)号：US11650209B2

公开(公告)日：2023-05-16

申请号：US16628427

申请日：2018-09-13

Applicant: KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

Inventor： Sang Taek Jung ,  Migyeong Jo ,  Sanghwan Ko ,  Bora Hwang

IPC: G01N33/53 ,  C12N5/00 ,  C12N15/00 ,  C07K16/46 ,  G01N33/68 ,  C07K14/735 ,  A61K38/00

CPC classification number: G01N33/6857 ,  C07K14/70535 ,  A61K38/00 ,  C07K16/46 ,  C07K2319/31 ,  C12N5/00 ,  C12N15/00 ,  G01N33/53

Abstract: The present disclosure relates to a polypeptide including an Fc-gamma receptor mutant. The Fc-gamma receptor mutant of the present disclosure is optimized by substituting a part of an amino acid sequence of an Fc-gamma receptor with a different amino acid sequence, so as to provide an excellent selective binding ability to immunoglobulins. Therefore, it can be usefully used for increasing in vivo half-life of drugs, detecting and purifying immunoglobulins, inhibiting organ transplant rejections, or preventing or treating autoimmune diseases.