公开(公告)号：US20170114104A1

公开(公告)日：2017-04-27

申请号：US15196533

申请日：2016-06-29

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yong Won JUNG ,  Jeong Min LEE

IPC: C07K14/195 ,  C07K14/47

CPC classification number: C07K14/195 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/24

Abstract: Disclosed are monomeric avidin-like proteins with a strong and stable biotin-binding ability, protein conjugates containing two or more of the monomeric avidin-like proteins and having a multivalent binding ability to biotin, nucleic acid molecules for encoding the monomeric avidin-like proteins, and methods for producing the monomeric avidin-like proteins, so the monomeric avidin-like proteins, due to the monomeric structure, are free from a problem of the disruption of receptor functions, caused by oligomerization occurring in existing tetrameric streptavidin or tetrameric but monovalent streptavidin variants.