公开(公告)号：US10016475B2

公开(公告)日：2018-07-10

申请号：US14404631

申请日：2013-05-29

申请人： KOREA FOOD RESEARCH INSTITUTE

发明人： Dong-Hwa Shon ,  Hee-Soon Shin ,  Min-Jung Bae ,  Ok-Hee Chai ,  Chang-Yuil Kang ,  Dae-Woon Choi ,  Gye-Young Choi ,  Jeong-Hae Rho ,  Jeong-Ryong Do

IPC分类号： A01N65/00 ,  A61K36/00 ,  A61K36/73 ,  A61K36/708 ,  A61K36/84 ,  A61K36/39 ,  A61K36/482 ,  A61K36/738 ,  A61K36/185 ,  A61K36/49 ,  A61K36/47 ,  A61K36/532 ,  A23L33/105

CPC分类号： A61K36/708 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/39 ,  A61K36/47 ,  A61K36/482 ,  A61K36/49 ,  A61K36/532 ,  A61K36/738 ,  A61K36/84 ,  A61K2300/00

摘要： The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

公开(公告)号：US20150118266A1

公开(公告)日：2015-04-30

申请号：US14404631

申请日：2013-05-29

申请人： KOREA FOOD RESEARCH INSTITUTE

发明人： Dong-Hwa Shon ,  Hee-Soon Shin ,  Min-Jung Bae ,  Ok-Hee Chai ,  Chang-Yuil Kang ,  Dae-Woon Choi ,  Gye-Young Choi ,  Jeong-Hae Rho ,  Jeong-Ryong Do

IPC分类号： A61K36/708 ,  A61K36/482 ,  A23L1/30 ,  A61K36/532 ,  A61K36/185 ,  A61K36/49 ,  A61K36/39 ,  A61K36/47

CPC分类号： A61K36/708 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/39 ,  A61K36/47 ,  A61K36/482 ,  A61K36/49 ,  A61K36/532 ,  A61K36/738 ,  A61K36/84 ,  A61K2300/00

摘要： The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

摘要翻译： 本发明提供了用于预防，改善或治疗Th1介导的免疫疾病或Th2介导的免疫疾病的组合物，抗组胺剂组合物和抗炎组合物。 本发明提供了用于预防，改善或治疗Th1介导的免疫疾病或Th2介导的免疫疾病的方法，抑制组胺释放的方法，以及预防，改善或治疗炎症性疾病的方法。 根据本发明的组合物对于IL-4的产生，肥大细胞的脱粒，COX-2,15-NOX和通过肠上皮细胞层的过敏原的通过或诱导的优良的Treg细胞具有优异的抑制活性 活动。 此外，本发明提供了天然物质和食用动物抗过敏物质的详细的作用机理，提供稳定性，降低生产成本，并且通过使用天然物质作为材料提高使用方便性。