公开(公告)号：US10993434B2

公开(公告)日：2021-05-04

申请号：US15836138

申请日：2017-12-08

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY

Inventor： Joung Han Yim ,  Il-Chan Kim ,  Se Jong Han ,  Ui Joung Youn ,  Hong Kum Lee ,  Sung Jin Kim ,  Pil-Sung Kang ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Ha Ju Park ,  Jin Haeng Song ,  Min Ju Kim ,  Ju Mi Hong ,  Dong-Gyu Jo

IPC: A01N1/02 ,  C12P19/04 ,  C12N1/20 ,  C12R1/01 ,  C08B37/00

Abstract: The present invention relates to an exopolysaccharide derived from Pseudoalteromonas sp. strain CY01 (KCTC 12867BP) which is a novel strain living in the polar regions, and to a composition for cryoprotection of cells, which contains the exopolysaccharide. The exopolysaccharide of the present invention has an excellent ability to cryoprotect cells, and shows no cytotoxicity. Thus, the inventive exopolysaccharide can substitute for conventional cryoprotective agents that show cytotoxicity when used at high concentrations.

公开(公告)号：US20180325101A1

公开(公告)日：2018-11-15

申请号：US15836138

申请日：2017-12-08

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY

Inventor： Joung Han Yim ,  Il-Chan Kim ,  Se Jong Han ,  Ui Joung Youn ,  Hong Kum Lee ,  Sung Jin Kim ,  Pil-Sung Kang ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Ha Ju Park ,  Jin Haeng Song ,  Min Ju Kim ,  Ju Mi Hong ,  Dong-Gyu Jo

IPC: A01N1/02 ,  C08B37/00 ,  C12P19/04

CPC classification number: A01N1/0221 ,  C08B37/006 ,  C12N1/20 ,  C12P19/04 ,  C12R1/01

Abstract: The present invention relates to an exopolysaccharide derived from Pseudoalteromonas sp. strain CY01 (KCTC 12867BP) which is a novel strain living in the polar regions, and to a composition for cryoprotection of cells, which contains the exopolysaccharide. The exopolysaccharide of the present invention has an excellent ability to cryoprotect cells, and shows no cytotoxicity. Thus, the inventive exopolysaccharide can substitute for conventional cryoprotective agents that show cytotoxicity when used at high concentrations.

公开(公告)号：US09968576B2

公开(公告)日：2018-05-15

申请号：US15520100

申请日：2014-10-24

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY

Inventor： Joung Han Yim ,  Il-Chan Kim ,  Se Jong Han ,  Dong-Gyu Jo

IPC: A61K31/198 ,  A61K45/06 ,  A61K31/45

CPC classification number: A61K31/198 ,  A61K31/167 ,  A61K31/17 ,  A61K31/175

Abstract: The present invention relates to a neurodegenerative disease treatment use, which is a novel use of Ramalin, and, more specifically, to a composition for preventing or treating neurodegenerative diseases, containing Ramalin, which has an inflammasome and BACE1 expression inhibitory activity. Ramalin according to the present invention has an effect of improving a cognitive ability by inhibiting the expression of an inflammatory factor, which contains an NLRP inflammasome protein, and BACE1, and is thus useful for preventing or treating memory disorder and neurodegenerative diseases.