公开(公告)号：US20250009832A1

公开(公告)日：2025-01-09

申请号：US18289284

申请日：2022-05-03

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： HWAN SUCK CHUNG ,  EUN-JI LEE ,  JANG GI CHOI ,  JI HYE KIM ,  YOUNG SOO KIM ,  TAEIN KIM ,  WEI LI

IPC: A61K36/739 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.