公开(公告)号：US20250009832A1

公开(公告)日：2025-01-09

申请号：US18289284

申请日：2022-05-03

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： HWAN SUCK CHUNG ,  EUN-JI LEE ,  JANG GI CHOI ,  JI HYE KIM ,  YOUNG SOO KIM ,  TAEIN KIM ,  WEI LI

IPC: A61K36/739 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.

公开(公告)号：US20250121020A1

公开(公告)日：2025-04-17

申请号：US18989473

申请日：2024-12-20

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： MALK EUN PAK ,  YOUNGHOON GO ,  WEI LI ,  HYE JIN YANG

IPC: A61K36/752 ,  A23K20/10 ,  A61K36/076 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/725 ,  A61K36/8888 ,  A61K36/9068 ,  A61P25/28

Abstract: A composition including Yukgunjatang as effective component is effective for improving memory and preventing, alleviating, or treating cognitive disorder. Yukgunjatang, which is prepared by boiling a mixture of Gingseng Radix, Atractylodes rhizoma alba, Hoelen, Glycyrrhizae Radix, Aurantii Nobilis Pericarpium, Pinelliae Rhizoma, Zingiberis Rhizoma, and Zizyphi Fructus in water, exhibits superior neuroprotective effect compared to individual extracts of Gingseng Radix, Atractylodes rhizoma alba, Hoelen, Glycyrrhizae Radix, Aurantii Nobilis Pericarpium, Pinelliae Rhizoma, Zingiberis Rhizoma, and Zizyphi Fructus, and, in an animal model of cognitive decline induced by scopolamine, administration of Yukgunjatang shows the effect of improving memory and cognitive function. Thus, the composition can be advantageously used as a food product, a medicinal product, or the like for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, and mild cognitive impairment.