公开(公告)号：US20250009832A1

公开(公告)日：2025-01-09

申请号：US18289284

申请日：2022-05-03

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： HWAN SUCK CHUNG ,  EUN-JI LEE ,  JANG GI CHOI ,  JI HYE KIM ,  YOUNG SOO KIM ,  TAEIN KIM ,  WEI LI

IPC: A61K36/739 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.

公开(公告)号：US20240252577A1

公开(公告)日：2024-08-01

申请号：US18290488

申请日：2022-05-31

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： HWAN SUCK CHUNG ,  JI HYE KIM ,  JANG GI CHOI ,  EUN-JI LEE ,  YOUNG SOO KIM

IPC: A61K36/73 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K36/73 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  A61K2236/331 ,  A61K2236/333

Abstract: A composition for inhibiting proliferation of tumor comprising Rubus coreanus extract as effective component. It was found that the Rubus coreanus extract binds to PD-L1 present on the surface of cancer cells, thus blocking the interaction between cancer cells and PD-1 on the surface of T cells to activate T cells and exhibit an inhibitory effect on tumor proliferation, and it was also found that the Rubus coreanus extract shows an excellent anti-tumor immune activity in humanized PD-1 animal model induced with MC38 colorectal cancer expressing human PD-L1 and also a synergistic effect when co-administered with anti-cancer agents.