公开(公告)号：US20210145912A1

公开(公告)日：2021-05-20

申请号：US17058861

申请日：2019-05-23

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Bo-Kyung PARK ,  Young Hwa KIM

IPC: A61K36/185 ,  A61P25/20 ,  A23L33/105

Abstract: A method for treating a sleep disorder according to an embodiment of the present disclosure includes administering a composition comprising an extract of Hibiscus syriacus as an effective ingredient to a subject in need thereof. Because the Hibiscus syriacus extract of the present invention has an effect of improving sleep time deteriorated by stress, and an effect of reducing the content of corticosterone, which increases due to stress, and increasing the content of serotonin in blood. In addition, the composition has an effect of enhancing in a significant sense the expression of GABAR A α1 in cerebral cortex, which decreases due to stress, in a group administered with Hibiscus syriacus extract. As such, the composition comprising Hibiscus syriacus extract as an effective ingredient as an effective ingredient can be advantageously used as a functional health food composition or a pharmaceutical composition for preventing, ameliorating or treating sleeping disorders.

公开(公告)号：US20210338761A1

公开(公告)日：2021-11-04

申请号：US17284574

申请日：2019-09-26

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Young Hwa KIM ,  Bo-Kyung PARK

IPC: A61K36/63 ,  A61P25/20 ,  A23L33/105

Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes an extract of Fraxinus sp. plant as an effective component. As the extract of Fraxinus rhynchophylla of the present invention has an effect of ameliorating sleep disturbance by increasing the mRNA expression level of calretinin, neuropeptide Y, GAD65 and GAD67 in an animal model which has sleep disturbance caused by stress, it can be advantageously used as a raw material of a functional health food or a pharmaceutical product for preventing, ameliorating, or treating sleep disturbance.

公开(公告)号：US20210346417A1

公开(公告)日：2021-11-11

申请号：US17284592

申请日：2019-09-26

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Young Hwa KIM ,  Bo-Kyung PARK

IPC: A61K31/7048 ,  A23L33/105 ,  A23L33/125

Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes administering to a subject in need thereof a composition including saponarin of Chemical Formula 1, a salt thereof acceptable for use in food, or a hydrate thereof as an effective component: In an animal model with lack of sleep caused by caffeine, saponarin of the present invention restores the travel distance, mobility time, mobility frequency, and immobility time to normal as well as increases the mRNA expression of neuropeptide Y, cholecystokinin, and GABA A α1 receptor, thereby alleviating sleep disturbance. Therefore, the saponarin of the present invention can be advantageously used as a raw material for a functional health food or a pharmaceutical product for preventing, alleviating, or treating sleep disturbance.

公开(公告)号：US20200306330A1

公开(公告)日：2020-10-01

申请号：US16755338

申请日：2018-10-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Bo-Kyung PARK ,  Young Hwa KIM

IPC: A61K36/63 ,  A61P25/24 ,  A61P25/22 ,  A23L33/105 ,  A23L33/00

Abstract: A method for preventing or treating at least one of depression and anxiety disorder according to an embodiment of the present invention includes administering to a subject in need thereof a composition having an extract of Fraxinus rhynchophylla as an effective ingredient. By having an effect of improving depressive behavior and low physical activity shown in an animal model with induced anxiety and depression, reducing the level of cortisol, increasing the level of serotonin, and also increasing the expression amount of pCERB, BDNF, and mBDNF proteins in hippocampal tissues, the compositions can be advantageously used for developing a functional health food product or a pharmaceutical product for ameliorating or treating the depression and anxiety disorder.