公开(公告)号：US20210338761A1

公开(公告)日：2021-11-04

申请号：US17284574

申请日：2019-09-26

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Young Hwa KIM ,  Bo-Kyung PARK

IPC: A61K36/63 ,  A61P25/20 ,  A23L33/105

Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes an extract of Fraxinus sp. plant as an effective component. As the extract of Fraxinus rhynchophylla of the present invention has an effect of ameliorating sleep disturbance by increasing the mRNA expression level of calretinin, neuropeptide Y, GAD65 and GAD67 in an animal model which has sleep disturbance caused by stress, it can be advantageously used as a raw material of a functional health food or a pharmaceutical product for preventing, ameliorating, or treating sleep disturbance.

公开(公告)号：US20200306330A1

公开(公告)日：2020-10-01

申请号：US16755338

申请日：2018-10-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Bo-Kyung PARK ,  Young Hwa KIM

IPC: A61K36/63 ,  A61P25/24 ,  A61P25/22 ,  A23L33/105 ,  A23L33/00

Abstract: A method for preventing or treating at least one of depression and anxiety disorder according to an embodiment of the present invention includes administering to a subject in need thereof a composition having an extract of Fraxinus rhynchophylla as an effective ingredient. By having an effect of improving depressive behavior and low physical activity shown in an animal model with induced anxiety and depression, reducing the level of cortisol, increasing the level of serotonin, and also increasing the expression amount of pCERB, BDNF, and mBDNF proteins in hippocampal tissues, the compositions can be advantageously used for developing a functional health food product or a pharmaceutical product for ameliorating or treating the depression and anxiety disorder.

公开(公告)号：US20210145912A1

公开(公告)日：2021-05-20

申请号：US17058861

申请日：2019-05-23

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Bo-Kyung PARK ,  Young Hwa KIM

IPC: A61K36/185 ,  A61P25/20 ,  A23L33/105

Abstract: A method for treating a sleep disorder according to an embodiment of the present disclosure includes administering a composition comprising an extract of Hibiscus syriacus as an effective ingredient to a subject in need thereof. Because the Hibiscus syriacus extract of the present invention has an effect of improving sleep time deteriorated by stress, and an effect of reducing the content of corticosterone, which increases due to stress, and increasing the content of serotonin in blood. In addition, the composition has an effect of enhancing in a significant sense the expression of GABAR A α1 in cerebral cortex, which decreases due to stress, in a group administered with Hibiscus syriacus extract. As such, the composition comprising Hibiscus syriacus extract as an effective ingredient as an effective ingredient can be advantageously used as a functional health food composition or a pharmaceutical composition for preventing, ameliorating or treating sleeping disorders.

公开(公告)号：US20210346417A1

公开(公告)日：2021-11-11

申请号：US17284592

申请日：2019-09-26

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Young Hwa KIM ,  Bo-Kyung PARK

IPC: A61K31/7048 ,  A23L33/105 ,  A23L33/125

Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes administering to a subject in need thereof a composition including saponarin of Chemical Formula 1, a salt thereof acceptable for use in food, or a hydrate thereof as an effective component: In an animal model with lack of sleep caused by caffeine, saponarin of the present invention restores the travel distance, mobility time, mobility frequency, and immobility time to normal as well as increases the mRNA expression of neuropeptide Y, cholecystokinin, and GABA A α1 receptor, thereby alleviating sleep disturbance. Therefore, the saponarin of the present invention can be advantageously used as a raw material for a functional health food or a pharmaceutical product for preventing, alleviating, or treating sleep disturbance.

公开(公告)号：US20150328121A1

公开(公告)日：2015-11-19

申请号：US14651876

申请日：2013-10-18

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Sung Uk CHAE ,  Mi Young LEE

IPC: A61K8/63 ,  A61Q19/08 ,  A61Q19/00

CPC classification number: A61K8/63 ,  A61K8/60 ,  A61K8/97 ,  A61K31/7028 ,  A61K31/704 ,  A61K31/7048 ,  A61K36/8964 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present invention relates to a skin-moisturizing or wrinkle-improving external composition or cosmetic composition which contains, as an active ingredient, a compound represented by Formula 1, which can be extracted from Anemarrhena asphodeloides Bunge, or a pharmaceutically acceptable salt thereof. The composition prevents skin moisture loss and thus suppresses skin tissue damage induced by UV rays and so has a skin-wrinkle preventing or alleviating effect.

Abstract translation: 本发明涉及皮肤保湿或皱纹改善的外用组合物或化妆品组合物或其药学上可接受的盐，其含有作为活性成分的可由Anemarrhena asphodeloides Bunge提取的由式1表示的化合物或其药学上可接受的盐。 该组合物防止皮肤水分流失，从而抑制由紫外线引起的皮肤组织损伤，因此具有防止或减轻皮肤皱纹的作用。

公开(公告)号：US20210213081A1

公开(公告)日：2021-07-15

申请号：US15998929

申请日：2017-02-10

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Goya CHOI ,  A Rang IM ,  Young Hwa KIM ,  Sung Wook CHAE

IPC: A61K36/185 ,  A23L33/105 ,  A61P25/24 ,  A61K9/00

Abstract: A method for preventing, ameliorating, or treating stress or depression includes administering a subject in need thereof a composition including a medicinal herb extract as an effective ingredient. Tt is shown that an extract of Hibiscus syriacus flower and an extract of Hibiscus syriacus root have an activity of protecting nerve cells, can lower the expression level of an inflammatory factor, which is increased by stress, and is effective for depression caused by stress.