公开(公告)号：US11926860B2

公开(公告)日：2024-03-12

申请号：US17485606

申请日：2021-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk Chung ,  Jinsu An ,  Eun Gyeong Yang ,  So Yeon Kim

IPC: C12Q1/02 ,  C12N9/64 ,  G01N33/58

CPC classification number: C12Q1/025 ,  C12N9/6472 ,  C12Y304/22057 ,  C12Q2527/127 ,  C12Y304/22036 ,  C12Y304/22055 ,  C12Y304/22056 ,  C12Y304/22062 ,  C12Y304/22064 ,  G01N33/582 ,  G01N2400/50 ,  G01N2500/00

Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.