公开(公告)号：US11926860B2

公开(公告)日：2024-03-12

申请号：US17485606

申请日：2021-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk Chung ,  Jinsu An ,  Eun Gyeong Yang ,  So Yeon Kim

IPC: C12Q1/02 ,  C12N9/64 ,  G01N33/58

CPC classification number: C12Q1/025 ,  C12N9/6472 ,  C12Y304/22057 ,  C12Q2527/127 ,  C12Y304/22036 ,  C12Y304/22055 ,  C12Y304/22056 ,  C12Y304/22062 ,  C12Y304/22064 ,  G01N33/582 ,  G01N2400/50 ,  G01N2500/00

Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.

公开(公告)号：US11766548B2

公开(公告)日：2023-09-26

申请号：US17153969

申请日：2021-01-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Industry-University Cooperation Foundation Hanyang University ERICA Campus

Inventor： Myoung-Ryul Ok ,  So Yeon Kim ,  Yoon Ki Joung ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Hyung-Seop Han ,  Hojeong Jeon ,  Hyunseon Seo ,  Inho Kim ,  Kyoung Won Park ,  Yongwoo Chung ,  Jaekyun Kim

IPC: A61M37/00 ,  A61N5/06

CPC classification number: A61M37/0015 ,  A61N5/062 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: Provided are phototherapeutic needle patches usable for phototherapy by using needle patches capable of injecting drugs or cosmetic substances to patients, and methods of manufacturing the same. A phototherapeutic needle patch may include a patch body attachable to skin of a patient, at least one microneedle protruding from the patch body, one end of the microneedle configured to deliver a drug through stratum corneum of the skin to inner tissues of the skin, and light grooves formed in a concave shape along a length direction of the microneedle in such a manner that therapeutic light radiated from a light source for phototherapy easily penetrates into the skin along the microneedle.