公开(公告)号：US20130251784A1

公开(公告)日：2013-09-26

申请号：US13774247

申请日：2013-02-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwang Meyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  Heebeom KOO ,  Sang-min LEE ,  Inchan YOUN

IPC: A61K47/26 ,  A61K47/34

CPC classification number: A61K47/26 ,  A61K47/34 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0052

Abstract: The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system.In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.

Abstract translation: 本公开内容涉及一种通过生物正交无铜点击化学体内靶向纳米颗粒的方法，更具体地涉及纳米颗粒的体内靶向方法，包括：注射能够在注射入体内时被代谢工程化的前体 生活系统，并具有第一生物正交功能组进入生活系统; 并且将具有第二生物正交官能团的纳米颗粒注射到与生物体系附着的第一生物正交官能团进行生物正交无铜点击反应。 根据本公开，可以显着增加生物体系中靶位点上的纳米颗粒的积累，并且可以控制纳米颗粒的生物分布，因为结合到细胞表面的纳米颗粒随时间被吸收到细胞中。

公开(公告)号：US20140163348A1

公开(公告)日：2014-06-12

申请号：US14080282

申请日：2013-11-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jinseok KIM ,  Jinwoo JEONG ,  Jun-Kyo Francis SUH ,  Kuiwon CHOI ,  Inchan YOUN

IPC: A61B5/04

CPC classification number: A61B5/04001 ,  A61N1/0551

Abstract: A neural tube capable of complexly playing roles of a support for regenerating a nerve and a nerve electrode has a support connected to a terminal of an injured nerve, and a sieve electrode having an electrode hole formed in a body thereof and a circular electrode formed around the electrode hole, wherein the body of the sieve electrode is buried in the support, wherein a cavity-type channel is formed at the support to extend to the inside of the support, wherein the electrode hole is aligned with the channel, and wherein a nerve cell growing along the channel at the terminal of the injured nerve is capable of contacting the circular electrode.

Abstract translation: 能够复合地起作用的再生神经和神经电极的支架的神经管具有连接到受损的神经的末端的支撑体，并且具有形成在其本体中的电极孔和形成在其周围的圆形电极的筛电极 所述电极孔，其中所述筛网电极的主体被埋在所述支撑件中，其中，在所述支撑件处形成空腔型通道以延伸到所述支撑件的内部，其中所述电极孔与所述通道对准，并且其中 沿着受伤神经末端的通道生长的神经细胞能够接触圆形电极。

公开(公告)号：US20200054262A1

公开(公告)日：2020-02-20

申请号：US16456139

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Inchan YOUN ,  Kuiwon CHOI ,  Hyung Min KIM ,  Suh-Yeon DONG ,  Hyunmyung CHO

IPC: A61B5/16 ,  A61B5/00 ,  G06N3/08 ,  G06N20/00 ,  G06F17/18

Abstract: The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

公开(公告)号：US20170055862A1

公开(公告)日：2017-03-02

申请号：US15185454

申请日：2016-06-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Inchan YOUN ,  Kuiwon CHOI ,  JUN-KYO FRANCIS SUH ,  Seung-Jong KIM ,  Hyung Min KIM ,  Youn Joo LEE ,  Inwon JUNG ,  Heesu PARK ,  Sunghee PARK ,  Jeong Hwan KIM

IPC: A61B5/0402 ,  A61B5/00

CPC classification number: A61B5/0402 ,  A61B5/0006 ,  A61B5/6824 ,  A61B5/6828 ,  A61B5/6829 ,  A61B5/6831 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475

Abstract: Disclosed is an apparatus for measuring electrocardiogram (ECG) using wireless communication, including a first measuring device and a second measuring device connected to each other using wireless communication, wherein the first measuring device includes a first electrode configured to measure a first signal generated by a heartbeat, and a slave signal generation unit configured to generate a slave signal based on the first signal and a wireless virtual ground signal received from the second measuring device, and the second measuring device includes a second electrode configured to measure a second signal generated by a heartbeat, a ground electrode configured to measure a ground signal, a wireless virtual ground unit configured to generate the wireless virtual ground signal based on the ground signal, and an ECG measuring unit configured to measure ECG based on the slave signal, the second signal, and the wireless virtual ground signal.

Abstract translation: 公开了一种使用无线通信测量心电图（ECG）的装置，包括使用无线通信彼此连接的第一测量装置和第二测量装置，其中第一测量装置包括第一电极，其被配置成测量由 心跳和从属信号生成单元，被配置为基于从第二测量装置接收到的第一信号和无线虚拟接地信号产生从属信号，并且第二测量装置包括第二电极，被配置为测量由第二信号 心跳线，接地电极，被配置为测量接地信号;无线虚拟接地单元，被配置为基于接地信号产生无线虚拟接地信号;以及ECG测量单元，被配置为基于从信号，第二信号， 和无线虚拟接地信号。

公开(公告)号：US20160016012A1

公开(公告)日：2016-01-21

申请号：US14748993

申请日：2015-06-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Inchan YOUN ,  Hyung Min KIM ,  Jinseok KIM ,  Kuiwon CHOI ,  Jong Woong PARK ,  Tae Young YUNE ,  Sungmin HAN ,  Yu Seon CHAE ,  Hoyoung JUNG

IPC: A61N7/00 ,  A61B5/0488

Abstract: A stimulation apparatus using low intensity focused ultrasound, which has a low intensity ultrasound focusing array having a plurality of transducers for outputting low intensity ultrasound beams, and a fixing device to which the low intensity ultrasound focusing array is attached, the fixing device being configured to fix the low intensity ultrasound focusing array to an upper body of a user. The low intensity ultrasound beams outputted from the transducers are focused to at least one focus. The focus is positioned to a spinal cord of the user or nerves around the spinal cord so that low intensity ultrasound stimulation is applied to the spinal cord or nerve cells of the nerves around the spinal cord.

Abstract translation: 一种使用低强度聚焦超声的刺激装置，其具有多个用于输出低强度超声波束的多个换能器的低强度超声聚焦阵列，以及固定所述低强度超声聚焦阵列的固定装置，所述固定装置被配置为 将低强度超声聚焦阵列固定到使用者的上身。 从换能器输出的低强度超声波束聚焦到至少一个焦点。 焦点定位于脊髓周围的使用者或神经的脊髓，使得低强度超声刺激被施加到脊髓周围的神经的脊髓或神经细胞。