公开(公告)号：US09259395B2

公开(公告)日：2016-02-16

申请号：US13906963

申请日：2013-05-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan Kwon ,  Kwang Meyung Kim ,  Kuiwon Choi ,  Heebeom Koo ,  Hyun Su Min ,  Inchan Youn

IPC: A61B8/00 ,  A61K9/51 ,  A61K49/22 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K9/00

CPC classification number: A61K9/5146 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5153 ,  A61K41/0028 ,  A61K47/6925 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/222 ,  A61K49/225

Abstract: A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.

Abstract translation: 肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和 用于药物递送的肿瘤靶向纳米颗粒。 由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。

公开(公告)号：US09901272B2

公开(公告)日：2018-02-27

申请号：US15185454

申请日：2016-06-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Inchan Youn ,  Kuiwon Choi ,  Jun-Kyo Francis Suh ,  Seung-Jong Kim ,  Hyung Min Kim ,  Youn Joo Lee ,  Inwon Jung ,  Heesu Park ,  Sunghee Park ,  Jeong Hwan Kim

IPC: A61B5/0428 ,  A61B5/0402 ,  A61B5/00

CPC classification number: A61B5/0402 ,  A61B5/0006 ,  A61B5/6824 ,  A61B5/6828 ,  A61B5/6829 ,  A61B5/6831 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475

Abstract: Disclosed is an apparatus for measuring electrocardiogram (ECG) using wireless communication, including a first measuring device and a second measuring device connected to each other using wireless communication, wherein the first measuring device includes a first electrode configured to measure a first signal generated by a heartbeat, and a slave signal generation unit configured to generate a slave signal based on the first signal and a wireless virtual ground signal received from the second measuring device, and the second measuring device includes a second electrode configured to measure a second signal generated by a heartbeat, a ground electrode configured to measure a ground signal, a wireless virtual ground unit configured to generate the wireless virtual ground signal based on the ground signal, and an ECG measuring unit configured to measure ECG based on the slave signal, the second signal, and the wireless virtual ground signal.

公开(公告)号：US20130323177A1

公开(公告)日：2013-12-05

申请号：US13906963

申请日：2013-05-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan Kwon ,  Kwang Meyung Kim ,  Kuiwon Choi ,  Heebeom Koo ,  Hyun Su Min ,  Inchan Youn

IPC: A61K9/51 ,  A61K49/22

CPC classification number: A61K9/5146 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5153 ,  A61K41/0028 ,  A61K47/6925 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/222 ,  A61K49/225

Abstract: A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.

Abstract translation: 肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和 用于药物递送的肿瘤靶向纳米颗粒。 由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。

公开(公告)号：US11317840B2

公开(公告)日：2022-05-03

申请号：US16456139

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Inchan Youn ,  Kuiwon Choi ,  Hyung Min Kim ,  Suh-Yeon Dong ,  Hyunmyung Cho

IPC: A61B5/16 ,  A61B5/00 ,  G06F17/18 ,  G06N3/08 ,  G06N20/00

Abstract: The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

公开(公告)号：US09801943B2

公开(公告)日：2017-10-31

申请号：US13774247

申请日：2013-02-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwang Meyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  Heebeom Koo ,  Sang-min Lee ,  Inchan Youn

IPC: A61K47/26 ,  A61K47/34 ,  A61K47/48 ,  A61K49/00

CPC classification number: A61K47/26 ,  A61K47/34 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0052

Abstract: The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system.In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.

公开(公告)号：US09220426B2

公开(公告)日：2015-12-29

申请号：US14080282

申请日：2013-11-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jinseok Kim ,  Jinwoo Jeong ,  Jun-Kyo Francis Suh ,  Kuiwon Choi ,  Inchan Youn

IPC: A61B5/04 ,  A61N1/05

CPC classification number: A61B5/04001 ,  A61N1/0551

Abstract: A neural tube capable of complexly playing roles of a support for regenerating a nerve and a nerve electrode has a support connected to a terminal of an injured nerve, and a sieve electrode having an electrode hole formed in a body thereof and a circular electrode formed around the electrode hole, wherein the body of the sieve electrode is buried in the support, wherein a cavity-type channel is formed at the support to extend to the inside of the support, wherein the electrode hole is aligned with the channel, and wherein a nerve cell growing along the channel at the terminal of the injured nerve is capable of contacting the circular electrode.

Abstract translation: 能够复合地起作用的再生神经和神经电极的支架的神经管具有连接到受损的神经的末端的支撑体，并且具有形成在其本体中的电极孔和形成在其周围的圆形电极的筛电极 所述电极孔，其中所述筛网电极的主体被埋在所述支撑体中，其中，在所述支撑件处形成空腔型通道以延伸到所述支撑件的内部，其中所述电极孔与所述通道对准，并且其中 沿着受伤神经末端的通道生长的神经细胞能够接触圆形电极。