公开(公告)号：US20170131233A1

公开(公告)日：2017-05-11

申请号：US14994389

申请日：2016-01-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong-Sik Shin ,  Jae-hoon Ji ,  Kyoseon Hwang ,  Tae Song Kim

IPC: G01N27/416 ,  G01N33/68 ,  G01N27/327

CPC classification number: G01N27/4166 ,  G01N27/3275 ,  G01N27/745 ,  G01N33/5438

Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.

公开(公告)号：US10648988B2

公开(公告)日：2020-05-12

申请号：US15878351

申请日：2018-01-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong-Sik Shin ,  Jae-hoon Ji ,  Youhee Heo ,  Kyoseon Hwang ,  Myung-Sic Chae

IPC: G01N33/53 ,  G01N25/18 ,  G01N24/00 ,  G01N27/00 ,  G01N33/68 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/1486 ,  C12Q1/6883

Abstract: A method for providing information relevant to the diagnosis of a neurodegenerative disorder. The method includes (i) obtaining a biological sample containing vesicles from a subject, (ii) measuring the level of amyloid beta in the biological sample using an antibody specific for the N-terminus of amyloid beta, and (iii) comparing the measured level of amyloid beta in the biological sample with the level of amyloid beta in a previously prepared control sample.

公开(公告)号：US11313828B2

公开(公告)日：2022-04-26

申请号：US14994389

申请日：2016-01-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong-Sik Shin ,  Jae-hoon Ji ,  Kyoseon Hwang ,  Tae Song Kim

IPC: G01N27/416 ,  G01N27/327 ,  G01N33/543

Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.