公开(公告)号：US20130324428A1

公开(公告)日：2013-12-05

申请号：US13689137

申请日：2012-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Chun Ryu ,  Mee Song ,  Ji-seong Yoon ,  Hyo Sun Lee ,  Wooin Ryu ,  Chan Young Shin

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: The present invention relates to a biomarker for the identification of specific exposure to lower aliphatic saturated aldehydes which are volatile organic compounds exposed in the environment, and a method for the identification of specific exposure to lower aliphatic saturated aldehydes using the same, precisely a biomarker which is up- or down-regulated specifically by lower aliphatic saturated aldehyde exposure and a method for the identification of specific exposure to lower aliphatic saturated aldehydes using the biomarker. The biomarker of the present invention is the reacted genes selected by using DNA microarray chip, which can be effectively used for the monitoring and evaluation of lower aliphatic saturated aldehyde contamination in the environment samples and at the same time as a tool for the investigation of the toxic mechanism induced specifically by lower aliphatic saturated aldehydes.

Abstract translation: 本发明涉及用于鉴定作为在环境中暴露的挥发性有机化合物的低级脂族饱和醛的特异性暴露的生物标志物，以及使用该生物标志物鉴定特定暴露于低脂肪族饱和醛的方法， 特别是通过低级脂族饱和醛暴露进行上调或下调，以及使用生物标志物鉴定对低级脂族饱和醛的特异性暴露的方法。 本发明的生物标志物是通过使用DNA微阵列芯片选择的反应基因，其可以有效地用于监测和评价环境样品中低级脂族饱和醛污染物，同时作为研究的工具 低级脂肪族饱和醛特异性诱导的毒性机制。

公开(公告)号：US08716192B2

公开(公告)日：2014-05-06

申请号：US13689216

申请日：2012-11-29

Applicant: Korea Institute of Science and Technology

Inventor： Jae Chun Ryu ,  Mee Song ,  Ji-seong Yoon ,  Wooin Ryu ,  Hyo Sun Lee ,  Chan Young Shin

IPC: C12Q1/68

CPC classification number: C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes.

Abstract translation: 本发明涉及通过使用微RNA鉴定暴露于低级脂族饱和醛的生物标志物以及使用其鉴定暴露于低级脂族饱和醛的方法。 在本发明中，选择通过暴露于低级脂族饱和醛上的至少1.5倍的微RNA和由其下调的低至0.66倍的微RNA。 这两种微RNA可以有效地用作监测低级脂肪族饱和醛的生物标志物，并可作为研究由这种低级脂族饱和醛引起的毒性机理的工具。

公开(公告)号：US20130324429A1

公开(公告)日：2013-12-05

申请号：US13689216

申请日：2012-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Chun Ryu ,  Mee Song ,  Ji-seong Yoon ,  Wooin Ryu ,  Hyo Sun Lee ,  Chan Young Shin

IPC: C12Q1/68

CPC classification number: C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes.

Abstract translation: 本发明涉及通过使用微RNA鉴定暴露于低级脂族饱和醛的生物标志物以及使用其鉴定暴露于低级脂肪族饱和醛的方法。 在本发明中，选择通过暴露于低级脂族饱和醛上的至少1.5倍的微RNA和由其下调的低至0.66倍的微RNA。 这两种微RNA可以有效地用作监测低级脂肪族饱和醛的生物标志物，并可作为研究由这种低级脂族饱和醛引起的毒性机理的工具。

公开(公告)号：US20130281311A1

公开(公告)日：2013-10-24

申请号：US13689042

申请日：2012-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Chun Ryu ,  Mee Song ,  Ji-seong Yoon ,  Hyo Sun Lee ,  Wooin Ryu ,  Chan Young Shin

IPC: C12Q1/68

CPC classification number: C12Q1/6813 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: The present invention relates to a biomarker for the identification of specific exposure to propionaldehyde which is one of volatile organic compounds exposed in the environment, and a method for the identification of specific exposure to propionaldehyde using the same, precisely a biomarker which is up-regulated or down-regulated specifically by propionaldehyde and a method for the identification of specific exposure to propionaldehyde using the biomarker. The biomarker of the present invention is the reacted genes selected by using DNA microarray chip, which can be effectively used for the monitoring and evaluation of propionaldehyde contamination in the environment samples and at the same time as a tool for the investigation of the toxic mechanism induced specifically by propionaldehyde.

Abstract translation: 本发明涉及用于鉴定作为在环境中暴露的挥发性有机化合物之一的丙醛的特异性暴露的生物标志物，以及使用该方法鉴定特异性暴露于丙醛的方法，精确地鉴定了上调的生物标志物 或通过丙醛特异性下调，以及使用生物标志物鉴定特异性暴露于丙醛的方法。 本发明的生物标志物是通过使用DNA微阵列芯片选择的反应基因，其可以有效地用于环境样品中丙醛污染的监测和评估，同时作为用于研究诱导的毒性机制的工具 特别是丙醛。