公开(公告)号：US20210244972A1

公开(公告)日：2021-08-12

申请号：US17103225

申请日：2020-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  Hyung Min KIM ,  Ki Joo PAHK ,  In Woo KIM ,  Su Hyun LEE

IPC: A61N7/00

Abstract: The present disclosure relates to a device capable of removing senescent cells by facilitating the phagocytosis of the senescent cells by specifically stimulating the senescent cells using an ultrasound output unit, a kit for removing senescent cells and a method for specifically removing senescent cells, and by selectively and specifically stimulating senescent cells by irradiating ultrasound under a specific condition, thereby promoting the secretion of various cytokines recruiting immune cells, only the senescent cells can be removed specifically and, furthermore, cell regeneration can be promoted.

公开(公告)号：US20200248141A1

公开(公告)日：2020-08-06

申请号：US16601853

申请日：2019-10-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  HyeRan GWAK ,  Eun Gyeong YANG

IPC: C12N5/0786 ,  A61K35/15

Abstract: Provided are a composition and a kit for reprogramming cancer associated fibroblasts (CAFs) into macrophages, and a method of using the same. According to a method of reprogramming CAFs according to an aspect, macrophages may be prepared with a high yield in a short period of time, and the tumor microenvironment may be suppressed and macrophages produced by reprogramming CAF may elimininate cancer cells. Therefore, the macrophages may be usefully applied as an anticancer agent or an anticancer adjuvant.

公开(公告)号：US20220186186A1

公开(公告)日：2022-06-16

申请号：US17387782

申请日：2021-07-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  Eun Gyeong YANG ,  HyeRan GWAK

IPC: C12N5/0786 ,  A61K35/15

Abstract: Provided are: a composition for inducing direct conversion from somatic cells into common myeloid progenitor cells, the composition including a chemical cocktail; a method of direct conversion of somatic cells into common myeloid progenitor cells and macrophages by using the composition; common myeloid progenitor cells or macrophages prepared by the method; a pharmaceutical composition for preventing or treating fibrosis or scars, cell therapeutics, a composition for screening drugs, and a 3D printable biomaterial composition for fabricating artificial tissues, each using the common myeloid progenitor cells or the macrophages.

公开(公告)号：US20190338265A1

公开(公告)日：2019-11-07

申请号：US16244361

申请日：2019-01-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12N9/50 ,  C12N15/70

Abstract: Provided is a method of producing monomeric caspase activation and recruitment domains (CARDs) in bacteria. According to this method, CARD domains may be easily produced in a monomeric form. Monomeric CARDs may be applied to studies on the mechanism of action of caspase, the development of new drugs, detection and elimination of endotoxins, development of cosmetics, etc.

公开(公告)号：US20220220529A1

公开(公告)日：2022-07-14

申请号：US17485606

申请日：2021-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12Q1/02 ,  C12N9/64

Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.

公开(公告)号：US20210220631A1

公开(公告)日：2021-07-22

申请号：US17153969

申请日：2021-01-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Industry-University Cooperation Foundation Hanyang University ERICA Campus

Inventor： Myoung-Ryul OK ,  So Yeon KIM ,  Yoon Ki JOUNG ,  Yu Chan KIM ,  Hyun Kwang SEOK ,  Hyung-Seop HAN ,  Hojeong JEON ,  Hyunseon SEO ,  Inho KIM ,  Kyoung Won PARK ,  Yongwoo CHUNG ,  Jaekyun KIM

IPC: A61M37/00 ,  A61N5/06

Abstract: Provided are phototherapeutic needle patches usable for phototherapy by using needle patches capable of injecting drugs or cosmetic substances to patients, and methods of manufacturing the same. A phototherapeutic needle patch may include a patch body attachable to skin of a patient, at least one microneedle protruding from the patch body, one end of the microneedle configured to deliver a drug through stratum corneum of the skin to inner tissues of the skin, and light grooves formed in a concave shape along a length direction of the microneedle in such a manner that therapeutic light radiated from a light source for phototherapy easily penetrates into the skin along the microneedle.

公开(公告)号：US20170191037A1

公开(公告)日：2017-07-06

申请号：US15224499

申请日：2016-07-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  Eun Gyeong YANG ,  Myung-Han YOON ,  Hyunju KIM

IPC: C12N5/074 ,  C12N5/00

CPC classification number: C12N5/0696 ,  C12N5/0075 ,  C12N2501/60 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2531/00 ,  C12N2535/00

Abstract: Provided are a method of culturing an induced pluripotent stem cell and a method of forming a spheroid of the induced pluripotent stem cell. According to an embodiment of the present inventive concept, the induced pluripotent stem cell may have improved stemness.