公开(公告)号：US20220220529A1

公开(公告)日：2022-07-14

申请号：US17485606

申请日：2021-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12Q1/02 ,  C12N9/64

Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.

公开(公告)号：US20220259633A1

公开(公告)日：2022-08-18

申请号：US17630657

申请日：2020-08-26

Applicant: EUBIOLOGICS CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chan Kyu LEE ,  Da Hui HA ,  Choon Geun LEE ,  Ye Ram LEE ,  Hak Suk CHUNG

IPC: C12P19/44

Abstract: Provided is a method of producing monophosphoryl lipid A (MPLA). According to the method, MPLA may be produced with high purity and high purity by using a bacterium producing MPLA.

公开(公告)号：US20170191071A1

公开(公告)日：2017-07-06

申请号：US15378681

申请日：2016-12-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Eun Gyeong YANG ,  Dohyeon HWANG

IPC: C12N15/70 ,  C12N15/52 ,  C12N9/10 ,  C12P19/12 ,  C12N9/16

CPC classification number: C12N15/70 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74 ,  C12P19/12

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.

公开(公告)号：US20220090065A1

公开(公告)日：2022-03-24

申请号：US17464691

申请日：2021-09-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae-Ro AHN ,  Jihyun PARK ,  Hak Suk CHUNG ,  Cherlhyun JEONG

IPC: C12N15/11 ,  C12N9/22

Abstract: The present invention relates to a novel trans-activating CRISPR RNA (tracrRNA) including a fragment of a tracrRNA, and a gRNA, a CRISPR-Cas9 system, and a kit including the tracrRNA.

公开(公告)号：US20190338265A1

公开(公告)日：2019-11-07

申请号：US16244361

申请日：2019-01-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12N9/50 ,  C12N15/70

Abstract: Provided is a method of producing monomeric caspase activation and recruitment domains (CARDs) in bacteria. According to this method, CARD domains may be easily produced in a monomeric form. Monomeric CARDs may be applied to studies on the mechanism of action of caspase, the development of new drugs, detection and elimination of endotoxins, development of cosmetics, etc.