公开(公告)号：US09233139B2

公开(公告)日：2016-01-12

申请号：US13861879

申请日：2013-04-12

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Semi Kim ,  Yunhee Lee

IPC: A61K38/17 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16

CPC classification number: A61K38/1703 ,  A61K38/17

Abstract: As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over-expression of C12orf59 protein or a fragment thereof inhibits cancer cell invasion, so that C12orf59 gene or a fragment thereof not only can be effectively used for the pharmaceutical composition for preventing and treating cancer but also can be used as a clinical marker for screening a cancer treatment agent candidate, for diagnosing various cancers or for predicting pathological stage. In addition, the C12orf59 gene or a fragment thereof of the present invention can be used for the method for preventing and treating cancer and for the preparation of a pharmaceutical composition for preventing and treating cancer.

Abstract translation: 如上所述，本发明的C12orf59基因抑制癌细胞侵袭并抑制癌细胞存活性，C12orf59蛋白或其片段的过表达抑制癌细胞侵袭，因此C12orf59基因或其片段不仅可以是 有效地用于预防和治疗癌症的药物组合物，但也可以用作筛选癌症治疗剂候选物，诊断各种癌症或用于预测病理分期的临床标志物。 此外，本发明的C12orf59基因或其片段可用于预防和治疗癌症的方法以及用于预防和治疗癌症的药物组合物的制备。

公开(公告)号：US09765118B2

公开(公告)日：2017-09-19

申请号：US14664048

申请日：2015-03-20

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Semi Kim ,  Yunhee Lee

IPC: A61K38/04 ,  C07K7/64 ,  C07K7/06 ,  C07K7/08 ,  A61K47/48 ,  A61K38/17 ,  A61K38/08 ,  A61K38/10 ,  A61K38/00

CPC classification number: C07K7/64 ,  A61K38/00 ,  A61K38/17 ,  A61K47/60 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6801 ,  A61K47/6811 ,  C07K7/06 ,  C07K7/08

Abstract: As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over expression of C12orf59 protein or a fragment thereof inhibits cancer cell invasion, so that C12orf59 gene or a fragment thereof not only can be effectively used for the pharmaceutical composition for preventing and treating cancer but also can be used as a clinical marker for screening a cancer treatment agent candidate, for diagnosing various cancers or for predicting pathological stage. In addition, the C12orf59 gene or a fragment thereof of the present invention can be used for the method for preventing and treating cancer and for the preparation of a pharmaceutical composition for preventing and treating cancer.

公开(公告)号：US20150259385A1

公开(公告)日：2015-09-17

申请号：US14664048

申请日：2015-03-20

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Semi Kim ,  Yunhee Lee

IPC: C07K7/64 ,  C07K7/08 ,  A61K47/48 ,  A61K38/10 ,  A61K38/08 ,  C07K7/06 ,  A61K38/12

CPC classification number: C07K7/64 ,  A61K38/00 ,  A61K38/17 ,  A61K47/60 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6801 ,  A61K47/6811 ,  C07K7/06 ,  C07K7/08

Abstract: As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over expression of C12orf59 protein or a fragment thereof inhibits cancer cell invasion, so that C12orf59 gene or a fragment thereof not only can be effectively used for the pharmaceutical composition for preventing and treating cancer but also can be used as a clinical marker for screening a cancer treatment agent candidate, for diagnosing various cancers or for predicting pathological stage. In addition, the C12orf59 gene or a fragment thereof of the present invention can be used for the method for preventing and treating cancer and for the preparation of a pharmaceutical composition for preventing and treating cancer.

Abstract translation: 如上所述，本发明的C12orf59基因抑制癌细胞侵袭并抑制癌细胞存活性，C12orf59蛋白或其片段的过表达抑制癌细胞侵袭，使得C12orf59基因或其片段不仅可以有效地 用于预防和治疗癌症的药物组合物，也可以用作筛选癌症治疗剂候选物，用于诊断各种癌症或用于预测病理分期的临床标志物。 此外，本发明的C12orf59基因或其片段可用于预防和治疗癌症的方法以及用于预防和治疗癌症的药物组合物的制备。

公开(公告)号：US20130202560A1

公开(公告)日：2013-08-08

申请号：US13861879

申请日：2013-04-12

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Semi Kim ,  Yunhee Lee

IPC: A61K48/00 ,  A61K38/17 ,  G01N33/574

CPC classification number: A61K38/1703 ,  A61K38/17

Abstract: As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over-expression of C12orf59 protein or a fragment thereof inhibits cancer cell invasion, so that C12orf59 gene or a fragment thereof not only can be effectively used for the pharmaceutical composition for preventing and treating cancer but also can be used as a clinical marker for screening a cancer treatment agent candidate, for diagnosing various cancers or for predicting pathological stage. In addition, the C12orf59 gene or a fragment thereof of the present invention can be used for the method for preventing and treating cancer and for the preparation of a pharmaceutical composition for preventing and treating cancer.

Abstract translation: 如上所述，本发明的C12orf59基因抑制癌细胞侵袭并抑制癌细胞存活性，C12orf59蛋白或其片段的过表达抑制癌细胞侵袭，因此C12orf59基因或其片段不仅可以是 有效地用于预防和治疗癌症的药物组合物，但也可以用作筛选癌症治疗剂候选物，诊断各种癌症或用于预测病理分期的临床标志物。 此外，本发明的C12orf59基因或其片段可用于预防和治疗癌症的方法以及用于预防和治疗癌症的药物组合物的制备。

公开(公告)号：US09266872B2

公开(公告)日：2016-02-23

申请号：US14256808

申请日：2014-04-18

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Semi Kim ,  Ill Young Lee ,  Hye-Jin Min ,  Eun-Hee Nam ,  Pilho Kim ,  Chang Soo Yun ,  Dong Joon Ko

IPC: A61K31/167 ,  A61K31/426 ,  C07D417/04 ,  C07D215/38 ,  C07D285/135 ,  C07D213/75 ,  C07D239/42 ,  C07D277/46 ,  C07D213/82 ,  C07D215/56 ,  C07D277/82 ,  A61K31/4439 ,  A61K31/428 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/5377

CPC classification number: C07D417/04 ,  A61K31/167 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/5377 ,  C07D213/75 ,  C07D213/82 ,  C07D215/38 ,  C07D215/56 ,  C07D239/42 ,  C07D277/46 ,  C07D277/82 ,  C07D285/135

Abstract: The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.

Abstract translation: 本发明涉及2-羟基芳基酰胺衍生物或其药学上可接受的盐，其制备方法和用于预防或治疗癌症的药物组合物，其包含其作为活性成分。 通过本发明制备的2-羟基芳基酰胺衍生物对TMPRSS4丝氨酸蛋白酶的活性的抑制和TMPRSS4表达的癌细胞的浸润的抑制是优异的，因此可以用作通过抑制来预防或治疗癌症的组合物 TMPRSS4在癌细胞，特别是结肠直肠癌，肺癌，乳腺癌，前列腺癌，卵巢癌，胰腺癌或胃癌细胞中过度表达。