公开(公告)号：US09902969B2

公开(公告)日：2018-02-27

申请号：US15319273

申请日：2015-06-16

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Eun Gyo Lee ,  Hong-Weon Lee ,  Shin Young Kang ,  Yeon-Gu Kim ,  Joon Ki Jung ,  Jungoh Ahn ,  Seung Hee Kang ,  Chun Sug Kim ,  Hyeok Won Lee ,  Jin Gyeom Lee

IPC: C12N15/85 ,  C12Q1/68 ,  C07K14/435 ,  C07K16/00

CPC classification number: C12N15/85 ,  C07K14/43595 ,  C07K16/00 ,  C07K2317/14 ,  C12N15/63 ,  C12N2840/203 ,  C12N2840/60 ,  C12N2840/85 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6897

Abstract: The present invention relates to a new gene fragment derived from Chinese hamster ovary (CHO) cell for enhancement of recombinant protein expression in animal cells and a use thereof. It has been found that using the vector comprising a gene fragment of the present invention enhances the expression of a target protein in animal cells. Accordingly, the vector comprising a gene fragment of the present invention could be usefully used in the production of biopharmaceuticals such as therapeutic antibodies, etc.