公开(公告)号：US20200085803A1

公开(公告)日：2020-03-19

申请号：US16470014

申请日：2017-12-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sungchan CHO ,  Miri CHOI ,  Joo Youn LEE

IPC: A61K31/444 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.

公开(公告)号：US20140057909A1

公开(公告)日：2014-02-27

申请号：US14070683

申请日：2013-11-04

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyun Sun LEE ,  Mun-Ock KIM ,  Yongseok CHOI ,  Kyeong Lee ,  Jeong-Jun PARK ,  Jee-Hee SEO ,  Hwayoung JUNG ,  Sungchan CHO

IPC: C07D401/12 ,  C07D295/155 ,  C07D209/20

CPC classification number: C07D401/12 ,  C07D209/12 ,  C07D209/14 ,  C07D209/20 ,  C07D209/26 ,  C07D295/155

Abstract: The present invention relates to an indole derivative, The indole derivative according to the present invention effectively inhibits the activity of diacylglycerol acyltransferase (DGAT) which induces metabolic diseases, such as obesity, diabetes, hyperlipidemia, or fatty liver and the like in lipid metabolism, thereby effectively regulating lipid metabolism and energy metabolism, and thus can be useful in pharmaceutical compositions for preventing or treating metabolic disease.

Abstract translation: 本发明涉及吲哚衍生物本发明的吲哚衍生物有效抑制二脂酰甘油酰基转移酶（DGAT）在脂质代谢中引起代谢性疾病如肥胖，糖尿病，高脂血症或脂肪肝等的活性， 从而有效地调节脂质代谢和能量代谢，因此可用于预防或治疗代谢疾病的药物组合物。

公开(公告)号：US20200207756A1

公开(公告)日：2020-07-02

申请号：US16495455

申请日：2018-03-23

Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hwan Geun CHOI ,  Eunhwa KO ,  Joong-heui CHO ,  Jung Beom SON ,  Yi Kyung KO ,  Jin-Hee PARK ,  So Young KIM ,  Seock Yong KANG ,  Seungyeon LEE ,  Hee Yoon RYU ,  Nam Doo KIM ,  Sang Bum KIM ,  Sun-Hwa LEE ,  Dayea KIM ,  Sun Joo LEE ,  Sungchan CHO ,  Kyu-Sun LEE ,  Kweon YU ,  Miri CHOI ,  Ja Wook KOO ,  Hyang-Sook HOE

IPC: C07D471/04 ,  A61P25/28

Abstract: The present invention relates to a pyrrolopyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

公开(公告)号：US20220106307A1

公开(公告)日：2022-04-07

申请号：US17398478

申请日：2021-08-10

Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hwan Geun CHOI ,  Eunhwa KO ,  Joong-heui CHO ,  Jung Beom SON ,  Yi Kyung KO ,  Jin-Hee PARK ,  So Young KIM ,  Seock Yong KANG ,  Seungyeon LEE ,  Hee Yoon RYU ,  Nam Doo KIM ,  Sang Bum KIM ,  Sun-Hwa LEE ,  Dayea KIM ,  Sun Joo LEE ,  Sungchan CHO ,  Kyu-Sun LEE ,  Kweon YU ,  Miri CHOI ,  Ja Wook KOO ,  Hyang-Sook HOE

IPC: C07D471/04 ,  A61P25/28

Abstract: The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.