公开(公告)号：US12186413B2

公开(公告)日：2025-01-07

申请号：US17441611

申请日：2020-03-27

Applicant: KOWA COMPANY, LTD.

Inventor： Misako Nakashima ,  Koichiro Iohara

IPC: A61K6/54 ,  A61K6/69 ,  A61K6/80 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/4725 ,  A61K38/18 ,  A61K38/19 ,  A61K38/48 ,  A61K45/06 ,  A61L27/22 ,  A61L27/36 ,  A61L27/54 ,  A61P1/02

Abstract: A non-cellular root canal filler comprises a tetrahydroisoquinoline compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt, and a dental tissue regeneration promotion kit comprises a pretreatment agent comprising a serine protease, and the non-cellular root canal filler.

公开(公告)号：US11969487B2

公开(公告)日：2024-04-30

申请号：US16651483

申请日：2018-09-21

Applicant: Kowa Company, Ltd.

Inventor： Misako Nakashima ,  Koichiro Iohara

IPC: A61K6/54 ,  A61K35/35 ,  A61K38/19 ,  A61K38/48 ,  A61K39/395 ,  A61K47/64 ,  A61L27/36 ,  A61L27/38 ,  A61L27/40 ,  A61P1/02

CPC classification number: A61K6/54 ,  A61K35/35 ,  A61K38/19 ,  A61K38/48 ,  A61K38/4826 ,  A61K39/395 ,  A61K47/642 ,  A61L27/36 ,  A61L27/3865 ,  A61L27/40 ,  A61P1/02

Abstract: A non-cellular dental tissue regeneration promoting kit is provided that makes effective dental tissue regeneration possible without transplantation of autologous or allogeneic stem cells or components derived from stem cells. The kit comprises: a pretreatment agent comprising a serine protease; and a non-cellular root canal filling material, the non-cellular root canal filling material comprising: a regeneration promoting compound including at least one of a CCR3 antagonist, a CCL11 neutralizing antibody, and an ALK5 inhibitor; and an extracellular matrix. The kit is preferably used for middle-aged or elderly individuals.