公开(公告)号：US20240229053A1

公开(公告)日：2024-07-11

申请号：US17928516

申请日：2022-05-31

申请人： KT&G CORPORATION

发明人： Hyo Seok SEO ,  Young Gi LEE ,  Jeong Heon LEE ,  Dong Sung JANG ,  Kwang Chul KIM ,  Woong Hyun NA

IPC分类号： C12N15/82 ,  C12N9/10 ,  C12N9/22

CPC分类号： C12N15/8243 ,  C12N9/1077 ,  C12N9/22 ,  C12N15/8205 ,  C12N2310/20 ,  C12Y204/02019

摘要： An aspect provides plant cells with an engineered QPT gene and methods of using the same. When a QPT gene in a plant cell is genetically engineered according to an aspect, biosynthesis of nicotine is effectively inhibited, and nicotine is reduced by about 97% or more, and since alkaloids other than nicotine (nornicotine, anabasine, anatabine) are also reduced by about 68% or more, plant cells with reduced carcinogen TSNAs (NNK, NNN, NAB, and NAT) may be produced.