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公开(公告)号：US11369264B2
公开(公告)日：2022-06-28
申请号：US16637210
申请日：2018-08-09
发明人： Norihiko Yokoi , Yuka Sugiura , Katsumi Yabusaki
摘要： A method for dynamically evaluating a tear fluid layer using an interference fringe image of the tear fluid layer composed of a plurality of consecutive frames, and includes: an image creation step of creating at least one break detection image of a first break detection image, a second break detection image, a third break detection image, and a fourth break detection image, which are images for detecting a breaking site of the tear fluid layer; a determination step of determining whether the break detection image created by the image creation step corresponds to a predetermined breakup pattern; a tally step of tallying the determination results determined by the determination step; and an evaluation step of evaluating, on the basis of a tallied result by the tally step, a breakup pattern of the interference fringe image of the tear fluid layer.
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公开(公告)号：US11107214B2
公开(公告)日：2021-08-31
申请号：US16609649
申请日：2018-04-27
发明人： Norihiko Yokoi , Katsumi Yabusaki
摘要： A method and device for evaluating the dynamics of a tear fluid layer to objectively and accurately evaluate breakdown of the tear fluid layer, which is a core mechanism of dry eye, are provided. The method includes a step of acquiring color information of each pixel in a predetermined region of a tear fluid layer interference fringe image, which is a moving image or a plurality of static images, a step of calculating a numerical value indicating the diversity of color from the acquired color information, a step of calculating the average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. The coefficient of variation is used as an index for evaluating the dynamics of the tear fluid layer.
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公开(公告)号：US11266308B2
公开(公告)日：2022-03-08
申请号：US16306398
申请日：2017-05-29
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
摘要： Provided are a method and a device for evaluating a tear fluid to objectively evaluate and determine the severity of dry eye or the like. Color information is acquired in a predetermined region of a tear fluid interference fringe image, a numerical value representing a color diversity is calculated from the color information acquired, and the numerical value representing the color diversity thus calculated is used as an index for evaluating a tear fluid state.
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4.发明申请公开(公告)号：US20140342469A1
公开(公告)日：2014-11-20
申请号：US14357550
申请日：2012-11-08
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/82 , G01N33/579
摘要： A method for measuring a specific physiologically active substance of biological origin includes preparing a mixed solution of an AL reagent and a sample containing the physiologically active substance and detecting the aggregation or gelatinization of a protein in the mixed solution while agitating the mixed solution, thereby detecting the physiologically active substance or measuring the concentration of the physiologically active substance in the sample. A predetermined fluorescence emission is imparted to a substance involved in the aggregation or gelatinization in the sample to be measured and/or the AL reagent, and the fluorescence emitted from the substance involved in the aggregation or gelatinization is measured or observed in the mixed solution. In this manner, the aggregation or gelatinization in the mixed solution can be detected.
摘要翻译： 用于测定生物来源的特定生理活性物质的方法包括制备AL试剂和含有生理活性物质的样品的混合溶液，并在搅拌混合溶液的同时检测混合溶液中蛋白质的聚集或凝胶化，从而检测 生理活性物质或测量样品中生理活性物质的浓度。 对被测定样品和/或AL试剂的凝集或凝胶化所涉及的物质赋予规定的荧光发射，并且在混合溶液中测定或观察从涉及聚集或凝胶化的物质发射的荧光。 以这种方式，可以检测混合溶液中的聚集或凝胶化。
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公开(公告)号：US11779205B2
公开(公告)日：2023-10-10
申请号：US16976375
申请日：2019-03-01
申请人： KOWA COMPANY, LTD.
发明人： Reiko Arita , Katsumi Yabusaki
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/1015 , A61B3/14 , G06F18/24 , G06V10/25 , G06V10/758 , G06V40/16
摘要： In classifying images by machine learning, provided are an image classification method, device, and program for classifying the image from which the feature difference is hardly detected, in particular, classifying the interference fringe image of tear fluid layer by the dry eye types. The method includes a step of acquiring a feature value from an interference fringe image of tear fluid layer for learning, a step of constructing a model for classifying an image from the feature value acquired from the interference fringe image of tear fluid layer for learning, a step of acquiring the feature value from an interference fringe image of tear fluid layer for testing, and a step of performing classification processing for classifying the interference fringe image of tear fluid layer for testing by types of dry eye using the model and the feature value acquired from the interference fringe image of tear fluid layer.
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公开(公告)号：US11514570B2
公开(公告)日：2022-11-29
申请号：US16637216
申请日：2018-08-06
申请人： KOWA COMPANY, LTD.
发明人： Reiko Arita , Katsumi Yabusaki
摘要： Provided are a method, a computer program and a device for noninvasively evaluating a state of a tear fluid and a tear fluid amount of a tear meniscus.
Included are a binarization step of binarizing a tear meniscus image, obtained by capturing at least a part of a tear meniscus of a subject, using a predetermined threshold value; an extraction step of extracting a high luminance region indicating a tear meniscus part from the binarized image; and an evaluation step of evaluating a tear fluid state on the basis of the high luminance region.-
公开(公告)号：US20200250818A1
公开(公告)日：2020-08-06
申请号：US16756928
申请日：2018-10-29
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
摘要： An analysis device includes: an acquirer that is configured to acquire data in which a physical quantity is associated with each unit area acquired by dividing a three-dimensional space, a three-dimensional time space, or a four-dimensional time space; a setter that is configured to set a detection region in a time space of three or more dimensions in the space or the time space and is configured to set a control region at a position surrounding a gap with the gap surrounding the detection region disposed in a space having the same dimensions as those of the detection region; and a determiner that is configured to determine whether or not one or more unit areas included in the detection region are predetermined areas on the basis of comparison between physical quantities of one or more unit areas included in the detection region and the control region set by the setter.
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公开(公告)号：US11717152B2
公开(公告)日：2023-08-08
申请号：US16627683
申请日：2018-07-03
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
CPC分类号： A61B3/101 , A61B3/14 , G06T7/0012 , G06T2207/10024 , G06T2207/30041
摘要： A method, a computer program and a device for evaluating a tear fluid layer non-invasively. The method, computer program, and device include a step of detecting a time when color information in a predetermined region in a tear fluid layer interference fringe image changes by a threshold value or more as an eyelid opening time, a step of extracting an image at the time when the predetermined time has passed from the eyelid opening time as an extracted image from the tear fluid interference fringe images, a determination value calculation step of calculating a determination value from the color information in a pixel in a local region by scanning a predetermined target region, a step of detecting a corresponding pixel by comparing the calculated determination value and a threshold value, and an evaluation step of evaluating tear fluid layer breakdown by comparing the detected pixel and a threshold value.
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9.发明授权公开(公告)号：US11328417B2
公开(公告)日：2022-05-10
申请号：US16756928
申请日：2018-10-29
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
摘要： A non-transitory computer-readable medium stores a program capable of improving the accuracy of detection of a target object. The program causes a computer to execute operations including, acquiring data in which a physical quantity is associated with each unit area acquired by dividing a given space; setting a detection region in a time space of three or more dimensions in the space or the time space; setting a control region at a position surrounding a gap with the gap surrounding the detection region disposed in a space having the same dimensions as those of the detection region; and determined whether or not one or more unit areas included in the detection region are predetermined areas on the basis of comparison between physical quantities of one or more unit areas included in the detection region and the control region that are set.
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10.发明授权公开(公告)号：US11200699B2
公开(公告)日：2021-12-14
申请号：US16609669
申请日：2018-04-27
申请人： KOWA COMPANY, LTD.
发明人： Katsumi Yabusaki
摘要： Provided are an analysis evaluation method and device, and a computer program for the state of a subject surface in a still image. The method includes: a step of acquiring color information of each pixel in a predetermined region in a still image, a step of calculating a numerical value indicating a diversity of color from the acquired color information, a step of calculating an average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. Herein, the coefficient of variation is used as an index for evaluating the surface state of an object.
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