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1.发明申请公开(公告)号：US20180327344A1
公开(公告)日：2018-11-15
申请号：US15777318
申请日：2016-11-18
发明人： Tomoya YOKOI , Hiroshi NAGANO , Takayuki SHIMIZU
CPC分类号： C07C59/01 , C07B2200/13 , C07C51/43 , C30B7/105 , C30B29/58
摘要： The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.
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公开(公告)号：US20210261493A1
公开(公告)日：2021-08-26
申请号：US17190981
申请日：2021-03-03
发明人： Tomoya YOKOI , Hiroshi NAGANO , Takayuki SHIMIZU
IPC分类号： C07C227/42 , C07C229/26 , C07C51/41 , C07C59/01 , C07C51/43 , C07C277/06 , C07C279/14
摘要： An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
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公开(公告)号：US20190210958A1
公开(公告)日：2019-07-11
申请号：US16311061
申请日：2017-06-23
发明人： Tomoya YOKOI , Hiroshi NAGANO , Takayuki SHIMIZU
IPC分类号： C07C227/42 , C07C229/26 , C07C279/14 , C07C277/06 , C07C59/01 , C07C51/41
CPC分类号： C07C227/42 , C07B2200/13 , C07C51/41 , C07C51/43 , C07C59/01 , C07C229/26 , C07C277/06 , C07C279/14
摘要： An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
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公开(公告)号：US20210221764A1
公开(公告)日：2021-07-22
申请号：US17259877
申请日：2019-07-12
发明人： Yuta YAMAGUCHI , Hiroshi NAGANO
IPC分类号： C07C51/43
摘要： An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.
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公开(公告)号：US20190071466A1
公开(公告)日：2019-03-07
申请号：US16083487
申请日：2017-03-10
发明人： Kazunari FUKUMOTO , Maya IGUCHI , Hiroshi NAGANO
摘要： According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
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公开(公告)号：US20200095279A1
公开(公告)日：2020-03-26
申请号：US16619081
申请日：2018-06-06
IPC分类号： C07K5/093
摘要： The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
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公开(公告)号：US20190135846A1
公开(公告)日：2019-05-09
申请号：US16099877
申请日：2017-05-08
发明人： Tomoya YOKOI , Hiroshi NAGANO , Kikue MASE , Masahiro ABE
IPC分类号： C07H3/06
摘要： An object of the present invention is to provide a crystal of 3′-sialyllactose (hereinafter, referred to as 3SL), which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a process for producing the same. The present invention relates to a 3SL sodium salt n-hydrate (wherein n represents any number of 0 to 9, and when n is 0, it is referred to as 3SL sodium salt anhydrate) and a process for producing the same.
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公开(公告)号：US20190085023A1
公开(公告)日：2019-03-21
申请号：US16083483
申请日：2017-03-10
发明人： Kazunari FUKUMOTO , Maya IGUCHI , Hiroshi NAGANO
摘要： The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 μm or more.
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9.发明申请公开(公告)号：US20180170959A1
公开(公告)日：2018-06-21
申请号：US15579592
申请日：2016-06-03
发明人： Maya IGUCHI , Kazunari FUKUMOTO , Hiroshi NAGANO
CPC分类号： C07K1/306 , C07K5/0215 , C07K5/06
摘要： The invention provides a method of efficiently and stably producing α-form crystal of reduced glutathione, and a preservation method thereof. According to the invention, development of β-form crystal and/or transition to β-form crystal of reduced glutathione are suppressed by the coexistence of at least one kind of compound selected from the group of aliphatic amino acid, sulfur-containing amino acid, aromatic amino acid, an analogous compound and dipeptide, as a habit modifier, during production and preservation of an aqueous solution or α-form crystal of reduced glutathione.
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公开(公告)号：US20200369721A1
公开(公告)日：2020-11-26
申请号：US16988335
申请日：2020-08-07
发明人： Kazunari FUKUMOTO , Maya IGUCHI , Hiroshi NAGANO
摘要： The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 μm or more.
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