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公开(公告)号：US20160138073A1
公开(公告)日：2016-05-19
申请号：US14898022
申请日：2014-07-07
CPC分类号： C12Q1/26 , C12N9/0006 , C12N9/0032 , C12Q1/37 , C12Y105/03 , G01N33/723 , G01N33/725 , G01N2333/805 , G01N2333/90672 , G01N2333/952
摘要： The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.
摘要翻译： 本发明提供了包含氨基酸序列的蛋白质，其中将包含SEQ ID NO：1所示氨基酸序列的蛋白质的61位精氨酸取代为选自甘氨酸，丙氨酸，缬氨酸， 亮氨酸，丝氨酸，苏氨酸，脯氨酸，半胱氨酸，甲硫氨酸，天冬酰胺，谷氨酰胺和天冬氨酸; 以及测定样品中的糖化血红蛋白的方法，其中所述方法包括使样品中的糖化血红蛋白与蛋白酶反应以产生糖化六肽，然后使产生的糖基化六肽与前述蛋白质反应，并测量产生或消耗的物质 通过反应。
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公开(公告)号：US20160123999A1
公开(公告)日：2016-05-05
申请号：US14897907
申请日：2014-07-07
IPC分类号： G01N33/72
CPC分类号： G01N33/723 , C12Q1/26 , G01N33/725
摘要： The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.
摘要翻译： 本发明提供了一种测定样品中糖化血红蛋白的方法，其包括直接氧化样品中的糖化血红蛋白，然后测量氧化产生或消耗的物质; 以及测定样品中糖化血红蛋白的方法，其包括使用酶直接氧化样品中的糖化血红蛋白，然后测量氧化产生或消耗的物质。 本发明的糖化血红蛋白测定方法可用于诊断与生活习惯有关的疾病如糖尿病。
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