公开(公告)号：US20120077690A1

公开(公告)日：2012-03-29

申请号：US13235005

申请日：2011-09-16

申请人： Kai Singbartl ,  John A. Kellum, JR.

发明人： Kai Singbartl ,  John A. Kellum, JR.

IPC分类号： C40B30/04 ,  G01N33/566

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.

摘要翻译： 本发明涉及肾脏疾病的预防和治疗领域。 可以根据长期透析的需要或期望来定制肾脏疾病的治疗。 例如，长期透析治疗的预测可以通过监测与慢性肾脏疾病发展有关的尿生物标志物来确定。 例如，测量透明质酸，死亡受体5和/或转化生长因子1的约14天的标准化时间过程可用于确定患有急性肾损伤的患者的恢复与非恢复的风险。

公开(公告)号：US20130323751A1

公开(公告)日：2013-12-05

申请号：US13981747

申请日：2012-01-20

申请人： Kai Singbartl ,  John A. Kellum, JR.

发明人： Kai Singbartl ,  John A. Kellum, JR.

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/60

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring urinary proteins can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury. Alternatively, the invention describes signature protein expression profiles to establish the probability of renal to recovery and/or renal non-recovery.

摘要翻译： 本发明涉及肾脏疾病的预防和治疗领域。 肾脏疾病的治疗可以根据肾脏恢复的需要或预期来定制。 例如，通过监测与慢性肾脏疾病发展相关的尿生物标志物可以确定肾脏恢复。 例如，测量尿蛋白的大约十四天的标准化时间过程可用于确定患有急性肾损伤的患者的恢复与非恢复的风险。 或者，本发明描述了标志蛋白表达谱，以确定肾恢复和/或肾不恢复的可能性。

公开(公告)号：US10557856B2

公开(公告)日：2020-02-11

申请号：US13235005

申请日：2011-09-16

申请人： Kai Singbartl ,  John A. Kellum, Jr.

发明人： Kai Singbartl ,  John A. Kellum, Jr.

IPC分类号： G01N33/68

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.

公开(公告)号：US08501489B2

公开(公告)日：2013-08-06

申请号：US12565483

申请日：2009-09-23

申请人： Kai Singbartl ,  John A. Kellum, Jr.

发明人： Kai Singbartl ,  John A. Kellum, Jr.

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N33/5308 ,  A61M1/14 ,  G01N33/543 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/52 ,  Y10T436/00 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis.

摘要翻译： 本发明涉及肾脏疾病的预防和治疗领域。 可以根据长期透析的需要或期望来定制肾脏疾病的治疗。 例如，长期透析治疗的预测可以通过监测与慢性肾脏疾病发展有关的尿生物标志物来确定。 例如，可以使用透明质酸的归一化时间过程来确定是否患有急性肾损伤的患者将需要长期透析。

公开(公告)号：US09551720B2

公开(公告)日：2017-01-24

申请号：US13981747

申请日：2012-01-20

申请人： Kai Singbartl ,  John A. Kellum, Jr.

发明人： Kai Singbartl ,  John A. Kellum, Jr.

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/60

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring urinary proteins can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury. Alternatively, the invention describes signature protein expression profiles to establish the probability of renal recovery and/or renal non-recovery.

摘要翻译： 本发明涉及肾脏疾病的预防和治疗领域。 肾脏疾病的治疗可以根据肾脏恢复的需要或预期来定制。 例如，通过监测与慢性肾脏疾病发展相关的尿生物标志物可以确定肾脏恢复。 例如，测量尿蛋白的大约十四天的标准化时间过程可用于确定患有急性肾损伤的患者的恢复与非恢复的风险。 或者，本发明描述了确定肾脏恢复和/或肾脏不恢复的可能性的特征蛋白质表达谱。

公开(公告)号：US20100081148A1

公开(公告)日：2010-04-01

申请号：US12565483

申请日：2009-09-23

申请人： Kai Singbartl ,  John A. Kellum, JR.

发明人： Kai Singbartl ,  John A. Kellum, JR.

IPC分类号： G01N33/53

CPC分类号： G01N33/5308 ,  A61M1/14 ,  G01N33/543 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/52 ,  Y10T436/00 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis.

摘要翻译： 本发明涉及肾脏疾病的预防和治疗领域。 可以根据长期透析的需要或期望来定制肾脏疾病的治疗。 例如，长期透析治疗的预测可以通过监测与慢性肾脏疾病发展有关的尿生物标志物来确定。 例如，可以使用透明质酸的归一化时间过程来确定是否患有急性肾损伤的患者将需要长期透析。

公开(公告)号：US20130252264A1

公开(公告)日：2013-09-26

申请号：US13825675

申请日：2011-09-23

申请人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf ,  Kai Singbartl ,  John A. Kellum

发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf ,  Kai Singbartl ,  John A. Kellum

IPC分类号： G01N33/53

CPC分类号： G01N33/5308 ,  G01N33/50 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.

摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用检测透明质酸（HA）中的一种或多种作为肾损伤中的诊断和预后生物标志物测定的测定法。

公开(公告)号：US20120201799A1

公开(公告)日：2012-08-09

申请号：US13500163

申请日：2010-10-07

申请人： William J. Federspiel ,  John Alston Kellum ,  Kai Singbartl

发明人： William J. Federspiel ,  John Alston Kellum ,  Kai Singbartl

IPC分类号： A61K35/12 ,  A61P37/00 ,  A61M1/00 ,  A61P35/00 ,  A61P9/00 ,  A61K35/14 ,  A61P29/00

CPC分类号： A61M1/3689 ,  A61K35/15 ,  A61K2035/124 ,  A61M1/3687

摘要： A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the patient. The agent can, for example, be immobilized via covalent bonding or ionic bonding to the at least one surface. The fluid can, for example, be blood or a blood fraction. The agent can, for example, be an agonist, an antagonist or an inverse agonist.

摘要翻译： 修饰细胞的方法包括从患者中去除包括细胞的流体，使来自患者的去除的液体与至少一个表面接触，在该表面上固定有至少一种与至少一种细胞受体相互作用的试剂以修饰流体中的细胞，并返回 流体到病人身上。 该试剂可以例如通过共价键或离子键固定至至少一个表面。 流体可以例如是血液或血液分数。 该试剂可以例如是激动剂，拮抗剂或反向激动剂。