公开(公告)号：US20150250815A1

公开(公告)日：2015-09-10

申请号：US14643757

申请日：2015-03-10

申请人： Kai-shun Christopher LEUNG ,  Ying Chau ,  Yu Yu

发明人： Kai-shun Christopher LEUNG ,  Ying Chau ,  Yu Yu

IPC分类号： A61K31/738 ,  A61K49/00 ,  A61K9/00

CPC分类号： A61K31/738 ,  A61K49/0008

摘要： The present invention provides a method for inducing chronic elevation of intraocular pressure in the eyes of an animal by introducing into the eyes a cross-linking hydrogel, an animal produced by this method, as well as a screening method useful for identifying compounds capable of modulating intraocular pressure as well as for identifying compounds capable of modulating retinal ganglion cell survival and/or regeneration.

摘要翻译： 本发明提供了一种通过向眼睛中引入交联水凝胶，通过该方法生产的动物以及用于鉴定能够调节的化合物的筛选方法来诱导动物眼睛中眼压的慢性升高的方法 眼压以及用于鉴定能够调节视网膜神经节细胞存活和/或再生的化合物。

公开(公告)号：US09895394B2

公开(公告)日：2018-02-20

申请号：US14643757

申请日：2015-03-10

申请人： Kai-shun Christopher Leung ,  Ying Chau ,  Yu Yu

发明人： Kai-shun Christopher Leung ,  Ying Chau ,  Yu Yu

IPC分类号： A61K31/738 ,  A61K49/00

CPC分类号： A61K31/738 ,  A61K49/0008

摘要： The present invention provides a method for inducing chronic elevation of intraocular pressure in the eyes of an animal by introducing into the eyes a cross-linking hydrogel, an animal produced by this method, as well as a screening method useful for identifying compounds capable of modulating intraocular pressure as well as for identifying compounds capable of modulating retinal ganglion cell survival and/or regeneration.

公开(公告)号：US09314421B2

公开(公告)日：2016-04-19

申请号：US12717180

申请日：2010-03-04

申请人： Ying Chau ,  Chi Yeung Cheung ,  Yu Yu

发明人： Ying Chau ,  Chi Yeung Cheung ,  Yu Yu

IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K39/395 ,  A61P27/02 ,  A61M37/00 ,  A61K9/00 ,  A61F9/00

CPC分类号： A61K9/0009 ,  A61F9/0017 ,  A61K9/0048 ,  A61M37/0092

摘要： The present invention provides a novel system and method for transscleral delivery of therapeutic agents, including macromolecules, into a target site in intrascleral space using ultrasound. Advantageously, the present invention not only significantly enhances transscleral diffusivity of macromolecular therapeutic agents, but also causes little damages to ocular tissues and structure.

摘要翻译： 本发明提供了一种新颖的系统和方法，用于使用超声波将治疗剂（包括大分子）经巩膜递送到膀胱内空间的靶位点。 有利地，本发明不仅显着增强了大分子治疗剂的经巩膜扩散性，而且对眼组织和结构几乎没有损伤。

公开(公告)号：US20140212373A1

公开(公告)日：2014-07-31

申请号：US14126725

申请日：2012-06-15

申请人： Ying Chau ,  Yu Yu

发明人： Ying Chau ,  Yu Yu

IPC分类号： A61K31/795 ,  A61K31/734 ,  A61K31/10 ,  A61K31/728 ,  A61K31/721

CPC分类号： A61K31/795 ,  A61K31/10 ,  A61K31/573 ,  A61K31/721 ,  A61K31/728 ,  A61K31/734 ,  C07K16/22

摘要： A multi-vinylsulfone containing molecule is described herein. The multi-vinylsulfone containing molecule can be formed by dissolving a water soluble polymer containing a hydroxyl group in an aqueous solution to form a polymer solution; adding a molecule containing two vinylsulfone groups to the polymer solution; and forming a modified polymer by controlling a number of the vinylsulfone groups that are added to the polymer. A hydrogel is also described herein that can include the multi-vinylsulfone containing molecule and a multi-thiol containing molecule. The hydrogel can be formed from an aqueous solution that includes the multi-vinylsulfone containing molecule and the multi-thiol containing molecule by undergoing gelatation upon delivery to a site in the body. Also described is a drug delivery system that employs the hydrogel.

摘要翻译： 本文描述了含有多乙烯基砜的分子。 含有多乙烯基砜的分子可以通过将含有羟基的水溶性聚合物溶解在水溶液中形成聚合物溶液而形成; 向聚合物溶液中加入含有乙烯基砜基团的分子; 以及通过控制添加到聚合物中的数量的乙烯基砜基来形成改性聚合物。 本文还描述了可以包括含有多乙烯基砜的分子和含多硫醇的分子的水凝胶。 水凝胶可以由含有多乙烯基砜的分子和含多硫醇的分子的水溶液形成，通过在递送到体内的部位时经历凝胶化。 还描述了采用水凝胶的药物递送系统。

公开(公告)号：US20100226971A1

公开(公告)日：2010-09-09

申请号：US12717180

申请日：2010-03-04

申请人： YING CHAU ,  Chi Yeung Cheung ,  Yu Yu

发明人： YING CHAU ,  Chi Yeung Cheung ,  Yu Yu

IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K39/395 ,  A61P27/02 ,  A61M37/00

CPC分类号： A61K9/0009 ,  A61F9/0017 ,  A61K9/0048 ,  A61M37/0092

摘要： The present invention provides a novel system and method for transscleral delivery of therapeutic agents, including macromolecules, into a target site in intrascleral space using ultrasound. Advantageously, the present invention not only significantly enhances transscleral diffusivity of macromolecular therapeutic agents, but also causes little damages to ocular tissues and structure.

摘要翻译： 本发明提供了一种新颖的系统和方法，用于使用超声波将治疗剂（包括大分子）经巩膜递送到膀胱内空间的靶位点。 有利地，本发明不仅显着增强了大分子治疗剂的经巩膜扩散性，而且对眼组织和结构几乎没有损伤。

公开(公告)号：US09592251B2

公开(公告)日：2017-03-14

申请号：US14126725

申请日：2012-06-15

申请人： Ying Chau ,  Yu Yu

发明人： Ying Chau ,  Yu Yu

IPC分类号： A61K9/14 ,  A61K39/29 ,  A61K31/74 ,  A61K31/715 ,  A61K31/795 ,  A61K31/573 ,  C07K16/22 ,  A61K31/10 ,  A61K31/721 ,  A61K31/728 ,  A61K31/734

CPC分类号： A61K31/795 ,  A61K31/10 ,  A61K31/573 ,  A61K31/721 ,  A61K31/728 ,  A61K31/734 ,  C07K16/22

摘要： A multi-vinylsulfone containing molecule is described herein. The multi-vinylsulfone containing molecule can be formed by dissolving a water soluble polymer containing a hydroxyl group in an aqueous solution to form a polymer solution; adding a molecule containing two vinylsulfone groups to the polymer solution; and forming a modified polymer by controlling a number of the vinylsulfone groups that are added to the polymer. A hydrogel is also described herein that can include the multi-vinylsulfone containing molecule and a multi-thiol containing molecule. The hydrogel can be formed from an aqueous solution that includes the multi-vinylsulfone containing molecule and the multi-thiol containing molecule by undergoing gelatation upon delivery to a site in the body. Also described is a drug delivery system that employs the hydrogel.

摘要翻译： 本文描述了含有多乙烯基砜的分子。 含有多乙烯基砜的分子可以通过将含有羟基的水溶性聚合物溶解在水溶液中形成聚合物溶液而形成; 向聚合物溶液中加入含有乙烯基砜基团的分子; 以及通过控制添加到聚合物中的数量的乙烯基砜基来形成改性聚合物。 本文还描述了可以包括含有多乙烯基砜的分子和含多硫醇的分子的水凝胶。 水凝胶可以由含有多乙烯基砜的分子和含多硫醇的分子的水溶液形成，通过在递送到体内的部位时经历凝胶化。 还描述了采用水凝胶的药物递送系统。

公开(公告)号：US08302319B1

公开(公告)日：2012-11-06

申请号：US13158864

申请日：2011-06-13

申请人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

发明人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

IPC分类号： G01B11/27

CPC分类号： G01C15/004

摘要： An apparatus for aligning a rail in a computer server rack has a laser transmitter for generating a laser dot. The apparatus has a prism for converting the laser dot into a laser line. The apparatus has a laser lens for projecting the laser line. The apparatus has an elongated bar for positioning the apparatus on a rack post, such that the laser line is projected perpendicular to the rack post.

摘要翻译： 用于对准计算机服务器机架中的轨道的装置具有用于产生激光点的激光发射器。 该装置具有用于将激光点转换成激光线的棱镜。 该装置具有用于投影激光线的激光透镜。 该设备具有用于将设备定位在齿条上的细长杆，使得激光线垂直于齿条柱投影。

公开(公告)号：US20120311878A1

公开(公告)日：2012-12-13

申请号：US13552429

申请日：2012-07-18

申请人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

发明人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

IPC分类号： G01B11/00

CPC分类号： G01C15/004

摘要： An apparatus for aligning a rail in a computer server rack has a laser transmitter for generating a laser dot. The apparatus has a prism for converting the laser dot into a laser line. The apparatus has a laser lens for projecting the laser line. The apparatus has an elongated bar for positioning the apparatus on a rack post, such that the laser line is projected perpendicular to the rack post.

摘要翻译： 用于对准计算机服务器机架中的导轨的装置具有用于产生激光点的激光发射器。 该装置具有用于将激光点转换成激光线的棱镜。 该装置具有用于投影激光线的激光透镜。 该设备具有用于将设备定位在齿条上的细长杆，使得激光线垂直于齿条柱投影。

公开(公告)号：US08247715B2

公开(公告)日：2012-08-21

申请号：US12764339

申请日：2010-04-21

申请人： Yu Yu

发明人： Yu Yu

IPC分类号： H01H9/28

CPC分类号： H01H9/283

摘要： A circuit breaker, comprising a locking device, a secondary cover and a tripbar operatively associated with the locking device. The locking device comprises a lock assembly and a piston assembly operatively coupled with the lock assembly. A through hole for the lock assembly is provided in the secondary cover. The lock assembly has a locked position and an unlocked position, and the piston assembly has a work position and a rest position respectively corresponding to the locked and unlocked positions. The piston assembly is configured to prevent the tripbar from moving to a relatch position when it is in the work position, such that the circuit breaker cannot be turned on. The locking device is configured to be installed on the circuit breaker through the through hole.

摘要翻译： 一种断路器，包括锁定装置，辅助盖和与所述锁定装置可操作地相关联的跳闸。 锁定装置包括锁定组件和与锁定组件可操作地联接的活塞组件。 用于锁组件的通孔设置在次盖中。 锁定组件具有锁定位置和解锁位置，并且活塞组件具有分别对应于锁定和解锁位置的工作位置和静止位置。 活塞组件被构造成防止跳闸在工作位置时移动到重合位置，使得断路器不能被接通。 锁定装置构造成通过通孔安装在断路器上。

公开(公告)号：US08418374B2

公开(公告)日：2013-04-16

申请号：US13552429

申请日：2012-07-18

申请人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

发明人： Wen Chen ,  ZhenDe Fu ,  Daniel Paul Kelaher ,  Lei Li ,  Yu Yu

IPC分类号： G01B11/27

CPC分类号： G01C15/004

摘要： An apparatus for aligning a rail in a computer server rack has a laser transmitter for generating a laser dot. The apparatus has a prism for converting the laser dot into a laser line. The apparatus has a laser lens for projecting the laser line. The apparatus has an elongated bar for positioning the apparatus on a rack post, such that the laser line is projected perpendicular to the rack post.

摘要翻译： 用于对准计算机服务器机架中的轨道的装置具有用于产生激光点的激光发射器。 该装置具有用于将激光点转换成激光线的棱镜。 该装置具有用于投影激光线的激光透镜。 该设备具有用于将设备定位在齿条上的细长杆，使得激光线垂直于齿条柱投影。