公开(公告)号：US08034397B2

公开(公告)日：2011-10-11

申请号：US12891967

申请日：2010-09-28

申请人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

发明人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

IPC分类号： G01N1/31

CPC分类号： G01N33/587 ,  G01N33/558

摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

摘要翻译： 提供了用于各种类型的测定装置的中空颗粒。 由于其中空或空隙结构，颗粒可能表现出各种有益的性质。 例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。 中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。 此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

公开(公告)号：US07829328B2

公开(公告)日：2010-11-09

申请号：US11440956

申请日：2006-05-25

申请人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

发明人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

IPC分类号： C12M1/34

CPC分类号： G01N33/587 ,  G01N33/558

摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

摘要翻译： 提供了用于各种类型的测定装置的中空颗粒。 由于其中空或空隙结构，颗粒可能表现出各种有益的性质。 例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。 中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。 此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

公开(公告)号：US20110020541A1

公开(公告)日：2011-01-27

申请号：US12891967

申请日：2010-09-28

申请人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

发明人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

IPC分类号： B05D7/02

CPC分类号： G01N33/587 ,  G01N33/558

摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

摘要翻译： 提供了用于各种类型的测定装置的中空颗粒。 由于其中空或空隙结构，颗粒可能表现出各种有益的性质。 例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。 中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。 此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

公开(公告)号：US06399295B1

公开(公告)日：2002-06-04

申请号：US09465921

申请日：1999-12-17

申请人： Rosann M. Kaylor ,  Abraham B. Choi ,  Chibueze Obinna Chidebelu-Eze ,  Michael Heinrich Herbert Grunze

发明人： Rosann M. Kaylor ,  Abraham B. Choi ,  Chibueze Obinna Chidebelu-Eze ,  Michael Heinrich Herbert Grunze

IPC分类号： G01N33569

CPC分类号： G01N33/54373 ,  B01J2219/00382 ,  C40B60/14 ,  Y10S435/808 ,  Y10S436/805

摘要： The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Finally, the system includes a wicking agent which permits the system to be a single step system which avoids the necessity of any additional rinsing steps. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image, such as a hologram, is produced which can be easily seen with the eye or, optionally, with a sensing device.

摘要翻译： 本发明提供了用于检测介质中存在的分析物的廉价且敏感的系统和方法。 该系统包括衍射增强元件，例如功能化微球，其被修饰使得它们能够与靶分析物结合。 此外，该系统包括聚合物膜，其可以包括金属涂层，在其上印刷特定的预定图案的分析物特异性受体。 最后，系统包括芯吸剂，其允许系统是单步系统，其避免了任何额外的漂洗步骤的必要性。 当将目标分析物直接或与衍射增强元件连接到聚合物膜的选择区域时，透射和/或反射光的衍射通过物理尺寸和限定的精确放置分析物而发生。 产生衍射图像，例如全息图，其可以用眼睛或可选地用感测装置容易地看到。

公开(公告)号：US07091049B2

公开(公告)日：2006-08-15

申请号：US10180219

申请日：2002-06-26

申请人： Rameshbabu Boga ,  Chibueze Obinna Chidebelu-Eze ,  Rosann M. Kaylor ,  Xuedong Song

发明人： Rameshbabu Boga ,  Chibueze Obinna Chidebelu-Eze ,  Rosann M. Kaylor ,  Xuedong Song

IPC分类号： G01N33/543

CPC分类号： G01N33/54373 ,  C12Q1/6825 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/817 ,  C12Q2563/107

摘要： An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance with the analyte of interest, the tag emitting a measurable parameter that is different from optical diffraction characteristics of the analyte. The biosensor may be a “fluoroptical” system wherein the detection tag is a fluorescence emitting substance, including fluorescent-labeled diffraction enhancing elements. The enhanced diffraction biosensor system may determine the presence of analytes in biological fluids both qualitatively and quantitatively.

摘要翻译： 提供了一种增强衍射的生物传感器系统和方法，用于检测测试介质中感兴趣的分析物。 该系统将至少一种额外的检测标签物质与感兴趣的分析物结合，该标签发射不同于分析物的光学衍射特性的可测量参数。 生物传感器可以是“荧光光谱”系统，其中检测标签是荧光发射物质，包括荧光标记的衍射增强元件。 增强的衍射生物传感器系统可以定性和定量地确定生物流体中分析物的存在。