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31 条记录 (耗时 0.029 秒)

    Stable oral compositions of azithromycin monohydrate
    1.
    发明申请
    Stable oral compositions of azithromycin monohydrate 审中-公开
    稳定的阿奇霉素一水合物的口服组合物

    公开(公告)号：US20070185194A1

    公开(公告)日：2007-08-09

    申请号：US10561827

    申请日：2004-07-01

    申请人： Kamal Mehta ,  Rajeev Mathur ,  Sujata Paul ,  Sanjeev Sethi ,  Rajiv Malik

    发明人： Kamal Mehta ,  Rajeev Mathur ,  Sujata Paul ,  Sanjeev Sethi ,  Rajiv Malik

    IPC分类号： A61K31/35

    CPC分类号： A61K9/0095 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K31/70

    摘要： The present invention relates to stable oral compositions of azithromycin monohydrate with reduced bitterness, processes for making these compositions, and methods of using these compositions for the treatment of microbial infections. The stable oral compositions of azithromycin include an azithromycin premix, at least one pharmaceutically accepted excipient, and, optionally, at least one taste-masking agent. The azithromycin premix includes azithromycin monohydrate and at least one additive.

    摘要翻译： 本发明涉及具有降低的苦味的阿奇霉素一水合物的稳定口服组合物，以及制备这些组合物的方法，以及使用这些组合物治疗微生物感染的方法。 阿奇霉素的稳定的口服组合物包括阿奇霉素预混物，至少一种药学上可接受的赋形剂和任选的至少一种掩味剂。 阿奇霉素预混物包括阿奇霉素一水合物和至少一种添加剂。

    Pharmaceutical compositions of ganciclovir
    4.
    发明申请
    Pharmaceutical compositions of ganciclovir 审中-公开
    更昔洛韦的药物组合物

    公开(公告)号：US20060189565A1

    公开(公告)日：2006-08-24

    申请号：US10532024

    申请日：2003-10-22

    申请人： Rajeev Mathur ,  Pananchukunnath Kumar ,  Sunilendu Roy ,  Rajiv Malik

    发明人： Rajeev Mathur ,  Pananchukunnath Kumar ,  Sunilendu Roy ,  Rajiv Malik

    IPC分类号： A61K31/7072

    CPC分类号： A61K9/2077 ,  A61K31/522

    摘要： The technical field of the invention relates to pharmaceutical compositions of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (ganciclovir) that are stable and contain more than 1% water content. One pharmaceutical composition includes ganciclovir having more than about 1% water content, and one or more pharmaceutically acceptable excipients. The ganciclovir retains at least about 97% of its initial purity after one month, at least about 96% of its initial purity after two months, and at least about 95% of its initial purity after three months when stored at 40° C. and 75% RH. In particular, the water content may be between about 2% and about 6%.

    摘要翻译： 本发明的技术领域涉及稳定且含有1％以上含水量的9-（1,3-二羟基-2-丙氧基甲基）鸟嘌呤（更昔洛韦）的药物组合物。 一种药物组合物包括具有超过约1％水含量的更昔洛韦和一种或多种药学上可接受的赋形剂。 更昔洛韦保存至少约97％的初始纯度一个月后，至少约96％的初始纯度两个月后，至少约95％的初始纯度三个月后储存在40°C和 75％RH。 特别地，水含量可以在约2％至约6％之间。

    Method and apparatus for configuration management in communications networks
    6.
    发明授权
    Method and apparatus for configuration management in communications networks 失效

    公开(公告)号：US5832503A

    公开(公告)日：1998-11-03

    申请号：US394143

    申请日：1995-02-24

    申请人： Rajiv Malik ,  Steve Sycamore ,  Bill Tracy

    发明人： Rajiv Malik ,  Steve Sycamore ,  Bill Tracy

    IPC分类号： H04L12/24 ,  G06F17/30

    CPC分类号： H04L41/20 ,  H04L41/0846 ,  H04L41/0866 ,  H04L41/0893 ,  Y10S707/99945

    摘要： Apparatus and method for monitoring parameters that govern the operational characteristics of a network device, including the use of templates for generating configuration records of network devices of a selected model type. A database of models is provided, each model representing an associated network device and including attribute values for the parameters of the associated network device. Templates are used to screen a model in order to retrieve values for each of the attributes and create a configuration record. The configuration records may be stored in the configuration manager or other storage device, and/or transferred to the pre-existing model database for use by a network management system in reconfiguring the associated network devices. This system for configuration management is less time consuming, expensive, and error prone than prior systems.

    Coating composition for taste masking coating and methods for their application and use
    8.
    发明申请
    Coating composition for taste masking coating and methods for their application and use 审中-公开
    用于掩味涂层的涂料组合物及其应用和用途的方法

    公开(公告)号：US20060159758A1

    公开(公告)日：2006-07-20

    申请号：US10538354

    申请日：2003-12-11

    申请人： Rajesh Gandhi ,  Chayapathy Issa ,  Rajiv Malik

    发明人： Rajesh Gandhi ,  Chayapathy Issa ,  Rajiv Malik

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0095 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/00

    摘要： The present invention relates to coating compositions for taste masking and methods for applying the coating compositions to dosage forms to mask the taste of a medicinal substance. The taste masking coating compositions generally include a copolymer of acrylate and methacrylate with a quaternary ammonium group in combination with sodium carboxymethylcellulose and a polyvinyl alcohol-polyethylene glycol copolymer.

    摘要翻译： 本发明涉及用于掩味的涂料组合物和将涂料组合物施用于剂型以掩盖药物的味道的方法。 掩味涂料组合物通常包括丙烯酸酯和甲基丙烯酸酯与季铵基团与羧甲基纤维素钠和聚乙烯醇 - 聚乙二醇共聚物的共聚物的共聚物。

    Bioavailable dosage form of isotretinoin
    10.
    发明授权
    Bioavailable dosage form of isotretinoin 失效
    异维A酸的生物可利用剂型

    公开(公告)号：US06740337B2

    公开(公告)日：2004-05-25

    申请号：US09829246

    申请日：2001-04-09

    申请人： Abha Pant ,  Inderdeep Bhatia ,  Sunilendu Bhushan Roy ,  Rajiv Malik

    发明人： Abha Pant ,  Inderdeep Bhatia ,  Sunilendu Bhushan Roy ,  Rajiv Malik

    IPC分类号： A61K914

    CPC分类号： A61K9/14 ,  A61K9/4858 ,  A61K31/07

    摘要： The present invention relates to a bioavailable pharmaceutical composition of 13-cis vitamin A acid (also known as 13-cis retinoic acid and isotretinoin) and a process for preparing the same. 13-cis vitamin A acid is a relatively water insoluble compound that degrades when exposed to light and atmospheric oxygen. Due to its instability and relative insolubility, the bioavailability of the drug after oral administration is difficult to achieve and has always been a challenge to a development pharmacist. It would therefore be desirable to provide a dosage form in which the drug is stable and predictably bioavailable.

    摘要翻译： 本发明涉及13-顺式维生素A酸（也称为13-顺式视黄酸和异维A酸）的生物可利用药物组合物及其制备方法。 13-顺式维生素A酸是一种相对不溶于水的化合物，当暴露于光和大气中时会降解。 由于其不稳定性和相对不溶性，口服给药后药物的生物利用度难以实现，并且一直是开发药剂师的挑战。 因此，期望提供其中药物是稳定的并且可预测地具有生物利用度的剂型。