公开(公告)号：US11135163B2

公开(公告)日：2021-10-05

申请号：US16109119

申请日：2018-08-22

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Tiffany L. Carter ,  Mark L. Weiss

IPC: A61K9/06 ,  A61K38/00 ,  A61L24/00 ,  A61L24/10

Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

公开(公告)号：US20220380731A1

公开(公告)日：2022-12-01

申请号：US17774968

申请日：2020-11-05

Applicant: Kansas State University Research Foundation

Inventor： Mark L. Weiss ,  Adrienne Wright

IPC: C12N5/0775

Abstract: Methods for improved handling of isolated canine umbilical cord mesenchymal stromal cells (UC-MSCs), including methods for expansion of canine UC-MSCs, cryopreservation and improved post-thaw viability using adherent plates, as well as standardized methods and kits for characterizing isolated canine UC-MSCs in a cell population. Methods for improved detachment or dissociation of adherent cells and new dissociation reagents comprising nattokinase are also disclosed.