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公开(公告)号：US20180353428A1
公开(公告)日：2018-12-13
申请号：US16109119
申请日：2018-08-22
Applicant: Kansas State University Research Foundation
Inventor： Xiuzhi S. Sun , Hongzhou Huang , Tiffany L. Carter
CPC classification number: A61K9/06 , A61K38/00 , A61L24/0031 , A61L24/108 , A61L2400/04 , C12N2513/00 , C12N2533/50
Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.
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公开(公告)号：US20170189334A1
公开(公告)日：2017-07-06
申请号：US15316398
申请日：2015-06-05
Applicant: Kansas State University Research Foundation
Inventor： Xiuzhi S. Sun , Hongzhou Huang , Tiffany L. Carter
CPC classification number: A61K9/06 , A61K38/00 , A61L24/0031 , A61L24/108 , A61L2400/04 , C12N2513/00 , C12N2533/50
Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.
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公开(公告)号：US20160030629A1
公开(公告)日：2016-02-04
申请号：US14434327
申请日：2013-12-06
Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Inventor： Xiuzhi S. Sun , Hongzhou Huang , Thu Annelise Nguyen
CPC classification number: A61L26/008 , A61K9/06 , A61K9/7007 , A61K47/42 , A61K47/64 , A61K47/643 , A61K47/6903 , A61L26/0028 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L26/0066 , A61L27/22 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/52 , A61L2300/252 , A61L2300/412 , A61L2300/418 , A61L2300/602 , A61L2300/62 , A61L2400/06 , C07K14/76
Abstract: Peptide-albumin hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and albumin. The peptide comprises a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.
Abstract translation: 描述了具有自组装的三维纳米纤维基质的肽 - 白蛋白水凝胶。 纳米纤维基质包含两亲肽和白蛋白。 肽包含末端疏水区域，中心转移区域和末端亲水区域。 还描述了制备这种水凝胶的方法以及使用水凝胶作为组织工程的支架作为3维细胞培养物和用于药物递送，活性剂（治疗细胞，分子，药物，化合物），细胞的包封的方法 移植，细胞储存，病毒培养和储存。
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公开(公告)号：US11135163B2
公开(公告)日：2021-10-05
申请号：US16109119
申请日：2018-08-22
Applicant: Kansas State University Research Foundation
Inventor： Xiuzhi S. Sun , Hongzhou Huang , Tiffany L. Carter , Mark L. Weiss
Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.
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