公开(公告)号：US20180312882A1

公开(公告)日：2018-11-01

申请号：US16034532

申请日：2018-07-13

申请人： Kao Corporation

发明人： Kougo Iida ,  Takumi Iwasaki ,  Tatsunari Nishi

IPC分类号： C12P7/42 ,  C12N15/52 ,  C12P7/44 ,  C12P7/40 ,  C12N1/20 ,  C12N9/10 ,  C12P13/14 ,  C12P13/06 ,  C12P13/20

CPC分类号： C12P7/42 ,  C12N1/20 ,  C12N9/1055 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/06 ,  C12P13/14 ,  C12P13/20

摘要： It is an object of the present invention to provide a bacterial strain that can decrease the amount of an intermediate Compound P converted into Metabolite M and efficiently accumulate Compound P in a medium that is not supplemented with Metabolite M or the final product generated from Metabolite M. The present invention provides a prokaryotic organism having all features (a) to (d) as defined in the specification so as to accumulate Compound P by regulating expression level of Enzyme X that converts Compound P as an intermediate metabolite into Metabolite M in a biosynthetic pathway in which Metabolite M indispensable for the growth is produced from a carbon source.

公开(公告)号：US10047382B2

公开(公告)日：2018-08-14

申请号：US14408400

申请日：2013-07-03

申请人： KAO CORPORATION

发明人： Kougo Iida ,  Takumi Iwasaki ,  Tatsunari Nishi

IPC分类号： C12P7/42 ,  C12N1/20 ,  C07H21/04 ,  C12P13/06 ,  C12P13/14 ,  C12P13/20 ,  C12P7/40 ,  C12P7/44 ,  C12N15/52 ,  C12N9/10

CPC分类号： C12P7/42 ,  C12N1/20 ,  C12N9/1055 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/06 ,  C12P13/14 ,  C12P13/20

摘要： It is an object of the present invention to provide a bacterial strain that can decrease the amount of an intermediate Compound P converted into Metabolite M and efficiently accumulate Compound P in a medium that is not supplemented with Metabolite M or the final product generated from Metabolite M. The present invention provides a prokaryotic organism having all features (a) to (d) as defined in the specification so as to accumulate Compound P by regulating expression level of Enzyme X that converts Compound P as an intermediate metabolite into Metabolite M in a biosynthetic pathway in which Metabolite M indispensable for the growth is produced from a carbon source.

公开(公告)号：US10781461B2

公开(公告)日：2020-09-22

申请号：US16034532

申请日：2018-07-13

申请人： Kao Corporation

发明人： Kougo Iida ,  Takumi Iwasaki ,  Tatsunari Nishi

IPC分类号： C12P7/42 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12N1/20 ,  C12P13/06 ,  C12P13/14 ,  C12P13/20 ,  C12N9/10

摘要： It is an object of the present invention to provide a bacterial strain that can decrease the amount of an intermediate Compound P converted into Metabolite M and efficiently accumulate Compound P in a medium that is not supplemented with Metabolite M or the final product generated from Metabolite M. The present invention provides a prokaryotic organism having all features (a) to (d) as defined in the specification so as to accumulate Compound P by regulating expression level of Enzyme X that converts Compound P as an intermediate metabolite into Metabolite M in a biosynthetic pathway in which Metabolite M indispensable for the growth is produced from a carbon source.