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公开(公告)号:US20100120050A1
公开(公告)日:2010-05-13
申请号:US12616701
申请日:2009-11-11
申请人: Kapil Gadkar , Ananth Kadambi , Cecelia Pearson , Lynn Powell , Scott Siler , Jeff Trimmer
发明人: Kapil Gadkar , Ananth Kadambi , Cecelia Pearson , Lynn Powell , Scott Siler , Jeff Trimmer
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/136 , C12Q2600/142
摘要: The invention also provides methods, apparatuses and reagents useful for predicting future atherosclerosis based on expression levels of genes selected from the set of 68 genes with differential expression in response to pioglitazone and rosiglitazone. The invention also discloses reagent sets and biomarkers for predicting progression of atherosclerosis induced by anti-diabetic therapy in a subject. In one particular embodiment the invention provides a method for predict whether a compound will induce atherosclerosis using gene expression data from sub-acute treatments.
摘要翻译: 本发明还提供了可用于预测未来动脉粥样硬化的方法,装置和试剂,其基于选自具有对吡格列酮和罗格列酮的差异表达的68个基因的基因的基因的表达水平。 本发明还公开了用于预测受试者中由抗糖尿病治疗引起的动脉粥样硬化进展的试剂组和生物标志物。 在一个具体实施方案中,本发明提供了使用来自亚急性治疗的基因表达数据来预测化合物是否将诱导动脉粥样硬化的方法。
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公开(公告)号:US20080249751A1
公开(公告)日:2008-10-09
申请号:US11875809
申请日:2007-10-19
申请人: Kapil GADKAR , Ananth Kadambi , Kortney Leabourne , Arthur Lo , Thomas S. Paterson , Lynn Powell
发明人: Kapil GADKAR , Ananth Kadambi , Kortney Leabourne , Arthur Lo , Thomas S. Paterson , Lynn Powell
CPC分类号: G16H50/50
摘要: The invention encompasses novel computer models of atherosclerosis and systems for predicting development and progression of atherosclerosis as well as associated cardiovascular risk. In particular, the computer model of atherosclerosis comprises a) a cholesterol metabolism module; b) an atherogenesis module; and c) a plaque stability module. The computer model optionally further comprises a cardiovascular risk module.
摘要翻译: 本发明包括动脉粥样硬化的新型计算机模型和用于预测动脉粥样硬化的发展和进展的系统以及相关的心血管风险。 特别地,动脉粥样硬化的计算机模型包括a)胆固醇代谢模块; b)动脉粥样硬化发生模块; 和c)斑块稳定性模块。 所述计算机模型还可包括心血管风险模块。
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公开(公告)号:US06764309B2
公开(公告)日:2004-07-20
申请号:US10093957
申请日:2002-03-06
申请人: Colette Cozean , Lynn Powell , Samir Nammour
发明人: Colette Cozean , Lynn Powell , Samir Nammour
IPC分类号: A61C500
CPC分类号: A61N5/0603 , A61N2005/0606 , A61N2005/0651 , A61N2005/067
摘要: A method and apparatus for preventing tooth decay by treating the tooth surface, including the occlusal surface and unexposed surfaces such as subgingival, interproximal, and contact areas, with a laser with a coherent or noncoherent light source are described. This process makes the tooth more resistant to acid and better able to bond fluoride, thus requiring a lower concentration of fluoride. The method allows the treatment to penetrate deeper into the tooth then previously accomplished with other methods and can be used in a dental office or at home.
摘要翻译: 描述了通过用具有相干或非相干光源的激光对牙齿表面进行处理以防止蛀牙的方法和装置,包括咬合面和未暴露的表面,例如龈下,邻间和接触区域。 该方法使得牙齿更耐酸,更好地粘合氟化物,因此需要较低浓度的氟化物。 该方法允许治疗深入牙齿,然后以其他方法先前完成,并且可以用于牙科诊所或在家中。
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公开(公告)号:US20050255053A1
公开(公告)日:2005-11-17
申请号:US11185380
申请日:2005-07-20
申请人: Colette Cozean , Lynn Powell , Samir Nammour
发明人: Colette Cozean , Lynn Powell , Samir Nammour
CPC分类号: A61K8/21 , A61C1/0046 , A61K2800/81 , A61Q11/00 , Y10S514/835
摘要: A method for preventing tooth decay by initially treating the tooth surface with a laser with a coherent or incoherent light source is provided. In one embodiment, this process makes the tooth more resistant to acid and more able to bond fluoride, thus requiring a lower concentration of fluoride. In one embodiment, the method allows for a deeper penetration of the tooth then previously accomplished with other methods. Low concentration fluoride compositions are also provided.
摘要翻译: 提供了一种通过用具有相干或非相干光源的激光器首先处理牙齿表面来防止蛀牙的方法。 在一个实施方案中,该方法使得牙齿更耐酸,更能够结合氟化物,因此需要较低浓度的氟化物。 在一个实施例中,该方法允许以前用其它方法完成的牙齿的较深穿透。 还提供了低浓度的氟化物组合物。
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公开(公告)号:US07163400B2
公开(公告)日:2007-01-16
申请号:US10890245
申请日:2004-07-13
申请人: Colette Cozean , Lynn Powell , Samir Nammour
发明人: Colette Cozean , Lynn Powell , Samir Nammour
CPC分类号: A61N5/0603 , A61N2005/0606 , A61N2005/0651 , A61N2005/067
摘要: A method and apparatus for preventing tooth decay by treating the tooth surface, including the occlusal surface and unexposed surfaces such as subgingival, interproximal, and contact areas, with a laser with a coherent or noncoherent light source are described. This process makes the tooth more resistant to acid and better able to bond fluoride, thus requiring a lower concentration of fluoride. The method allows the treatment to penetrate deeper into the tooth then previously accomplished with other methods and can be used in a dental office or at home.
摘要翻译: 描述了通过用具有相干或非相干光源的激光对牙齿表面进行处理以防止蛀牙的方法和装置,包括咬合面和未暴露的表面,例如龈下,邻间和接触区域。 该方法使得牙齿更耐酸,更好地粘合氟化物,因此需要较低浓度的氟化物。 该方法允许治疗深入牙齿,然后以其他方法先前完成,并且可以用于牙科诊所或在家中。
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公开(公告)号:US06939535B2
公开(公告)日:2005-09-06
申请号:US10039291
申请日:2002-01-03
申请人: Colette Cozean , Lynn Powell , Samir Nammour
发明人: Colette Cozean , Lynn Powell , Samir Nammour
CPC分类号: A61K8/21 , A61C1/0046 , A61C5/00 , A61K2800/81 , A61Q11/00 , Y10S514/835
摘要: A method for preventing tooth decay by initially treating the tooth surface with a laser with a coherent or noncoherent light source. This process makes the tooth more resistant to acid and more able to bond fluoride, thus requiring a lower concentration of fluoride. The method allows for a deeper penetration of the tooth then previously accomplished with other methods.
摘要翻译: 通过用具有相干或非相干光源的激光器首先处理牙齿表面来防止蛀牙的方法。 该方法使得牙齿更耐酸,更能够结合氟化物,因此需要较低浓度的氟化物。 该方法允许牙齿更深地穿透,然后用其它方法预先完成。
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