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公开(公告)号：US5246457A
公开(公告)日：1993-09-21
申请号：US629074
申请日：1990-12-17
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译： 公开了一种用于骨修复的组合物，特别是在仅包含磷酸钙矿物颗粒与阿替肽重构纤维状胶原蛋白制剂混合的方法中。 该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。 用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。
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2.发明授权Method of making molds with xenogeneic collagen/mineral preparations for bone repair 失效用于骨修复的异种胶原蛋白/矿物质制剂的制备方法
公开(公告)号：US4992226A
公开(公告)日：1991-02-12
申请号：US245449
申请日：1988-09-16
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S623/901 , Y10S623/923
摘要： A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.
摘要翻译： 公开了一种通过将胶原蛋白泵送通过模塑基质来涂覆矿物基质的孔的方法。 所得涂层基质可用作骨修复中的假体。
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公开(公告)号：US5425770A
公开(公告)日：1995-06-20
申请号：US99610
申请日：1993-07-30
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.
摘要翻译： 公开了用于制备用于导电骨修复的组合物的方法。 组合物含有基本上由磷酸钙颗粒状矿物组分或颗粒状羟基磷灰石组成的混合物，与磷酸腺苷重构的纤维状胶原混合。 该方法包括混合胶原蛋白和矿物质的分散体，后者以干燥颗粒形式存在，然后在模具中成型和干燥组合物以获得干燥的组合物。
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公开(公告)号：US4795467A
公开(公告)日：1989-01-03
申请号：US848443
申请日：1986-04-04
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S514/801
摘要： A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译： 公开了一种用于骨修复的组合物，特别是在包含磷灰石矿物颗粒与阿替肽复构的纤维状胶原蛋白制剂混合的敷贴方法中。 该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。 用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。
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公开(公告)号：US4016270A
公开(公告)日：1977-04-05
申请号：US627591
申请日：1975-10-31
CPC分类号： A61K9/0039 , A61K31/56
摘要： A method for treating dysmenorrhea is disclosed. The method comprises administering to the uterus of a warm blooded animal having dysmenorrhea controlled and continuous low dosage amounts of a progestational hormone to impart symptomatic relief from dysmenorrhea.
摘要翻译： 公开了治疗痛经的方法。 该方法包括向子宫内给予具有痛经控制和连续低剂量的孕激素的温血动物以赋予痛经症状缓解。
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公开(公告)号：US4014988A
公开(公告)日：1977-03-29
申请号：US627506
申请日：1975-10-31
CPC分类号： A61K9/0039 , A61K31/56
摘要： A method for treating hypermenorrhea is disclosed. The method comprises continuously administering controlled low dosage amounts of a progestational hormone to the uterus to impart relief from hypermenorrhea.
摘要翻译： 公开了一种治疗经痛的方法。 该方法包括向子宫连续施用控制低剂量的孕激素以缓解经痛。
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公开(公告)号：US4803075A
公开(公告)日：1989-02-07
申请号：US878418
申请日：1986-06-25
CPC分类号： A61K38/39 , A61L27/24 , A61L27/26 , A61L27/50 , A61F2/0059 , A61F2310/00365 , A61L2400/06 , Y10S514/801 , Y10S514/802
摘要： Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.
摘要翻译： 公开了含有生物相容性流体润滑剂（例如糖原或麦芽糖）的生物材料的可注射水性悬浮液，例如交联胶原蛋白。 润滑剂的包含显着地改善了悬浮液侵入软组织中。
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公开(公告)号：US5428022A
公开(公告)日：1995-06-27
申请号：US921810
申请日：1992-07-29
申请人： Howard Palefsky , Bruce B. Pharriss , George Chu
发明人： Howard Palefsky , Bruce B. Pharriss , George Chu
CPC分类号： A61L27/24 , A61F2310/00365
摘要： A human placental collagen composition for use in soft tissue augmentation comprising an aqueous suspension of a homogenized nonirradiation-sterilized mixture of type I and type III human placental collagen, wherein the type III collagen constitutes less than about 10% by weight of the mixture.
摘要翻译： 一种用于软组织增强的人胎盘胶原组合物，其包含I型和III型人胎盘胶原的均匀化非照射灭菌混合物的水性悬浮液，其中III型胶原构成混合物的约10重量％。
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公开(公告)号：US4440750A
公开(公告)日：1984-04-03
申请号：US348414
申请日：1982-02-12
CPC分类号： A61L27/3608 , A61F2/28 , A61L27/24 , A61L27/365 , A61F2310/00365 , Y10S514/801 , Y10S623/919
摘要： A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction site. Once emplaced the dispersion induces rapid and complete osteogenesis at the site.
摘要翻译： 在具有基本生理pH和离子强度的连续水相中，软化骨粉末和复原天然阿托肽胶原纤维的塑料分散体用于通过将其注入或植入修复或施工部位来修复或构建骨。 一旦放置，该分散体在该部位引起快速且完整的成骨。
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10.发明授权Delivery system with mated members for storing and releasing a plurality of beneficial agents 失效具有用于存储和释放多个有益试剂的配合构件的输送系统
公开(公告)号：US4237885A
公开(公告)日：1980-12-09
申请号：US953480
申请日：1978-10-23
CPC分类号： A61F6/08 , A61K9/0036 , A61M31/002
摘要： A delivery system is disclosed. The system is useful for the preprogrammed, unattended delivery of at least one beneficial agent to a pre-selected environment of use. The system comprises (I), a beneficial agent (II), a delivery module comprising, (a) a closed tubular member twined about itself to form a multiplicity of continuous, entwined, mated members, the members having, (b) an internal reservoir for storing agent in an amount for execution of the program, (c) a rate controller which maintains the rate of agent delivered in an effective amount from the members throughout the life of the system, (d) an energy source for transferring agent from the reservoir to the environment, and, (e) a portal for releasing agent from the members to the environment, (III), a platform which integrates the module into a unit sized, shaped and adapted for insertion and retention in the environment, and, (IV) a program which provides for the controlled release of agent to produce the desired beneficial effect over a prolonged period of time.
摘要翻译： 公开了传送系统。 该系统对于预先选择的使用环境中的至少一种有益试剂的预编程的，无人值守的递送是有用的。 所述系统包括（I），有益剂（II），递送模块，其包括：（a）围绕其自身缠绕的密封管状构件，以形成多个连续的，缠结的配合构件，所述构件具有（b）内部 用于存储执行程序的存储器的存储器，（c）速率控制器，其在系统的整个寿命期间保持从成员有效量传递的代理程序的速率，（d）转移代理从 （e）用于将成员从成员释放到环境的门户，（III），将模块整合成尺寸，形状并适于插入和保持在环境中的单元的平台，以及 ，（IV）一个程序，其规定了药剂的控制释放以在长时间内产生期望的有益效果。
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