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    Synergistically active veterinary compositions and process for preparing same
    1.
    发明授权
    Synergistically active veterinary compositions and process for preparing same 失效
    合成活性兽药组合物及其制备方法

    公开(公告)号：US5120711A

    公开(公告)日：1992-06-09

    申请号：US616813

    申请日：1990-11-20

    申请人： Karoly Magyar ,  Ferenc Simon ,  Janos Varga ,  Attila Nagy ,  Laszlo Puskas ,  Pal Fekete ,  Janos Egri ,  Katalin Zukovics

    发明人： Karoly Magyar ,  Ferenc Simon ,  Janos Varga ,  Attila Nagy ,  Laszlo Puskas ,  Pal Fekete ,  Janos Egri ,  Katalin Zukovics

    IPC分类号： A61K38/00 ,  A61K38/04 ,  A61P15/00 ,  A61P15/14

    CPC分类号： A61K38/04

    摘要： The invention relates to synergistically active veterinary compositions useful particularly for the treatment of mastitis and metritis. The invention further relates to a process for preparing these compositions. The compositions according to the invention comprise, based on 1 part by weight of 6,9,18-tris(2-aminoethyl) -15-benzyl-21-[.sup.- 2,8-bis(2-aminoethyl)-5-(1-hydroxyethyl) -15-methyl-4,7,10-trioxo-3,6,9-triazaheptadecanamido]-3-(1-hydroxyethyl)-12-isobutyl-1,4,7,10,13,16,19-heptaazacyclotricosane-2, 5,8,11,14,17,20-heptaone or a pharmaceutically acceptable acid addition salt thereof, 1 to 1000 parts by weight of 1-(2-chlorophenyl)-diphenylmethyl-1H-imidazole or 1 to 400 parts by weight of 2-methyl-5,7-dichloro-8-hydroxyquinoline, respectively, optionally in admixture with carriers and/or additives commonly used in the pharmaceutical industry.

    摘要翻译： 本发明涉及特别用于治疗乳腺炎和子宫炎的协同作用的兽医学组合物。 本发明还涉及制备这些组合物的方法。 根据本发明的组合物包含基于1重量份的6,9,18-三（2-氨基乙基）-15-苄基-21 - [ - 2,8-双（2-氨基乙基）-5-（ 1-羟乙基）-15-甲基-4,7,10-三氧代-3,6,9-三氮杂十七烷酰胺基] -3-（1-羟基乙基）-12-异丁基-1,4,7,10,13,16 ，19-七氮杂环五烷-2,5,8,11,14,17,20-七酮或其药学上可接受的酸加成盐，1〜1000重量份的1-（2-氯苯基） - 二苯基甲基-1H-咪唑或 1至400份（重量）的2-甲基-5,7-二氯-8-羟基喹啉，分别任选与制药工业中通常使用的载体和/或添加剂混合。

    Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor
    4.
    发明授权
    Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor 失效
    使用环肽抑制与尿激酶型纤溶酶原激活物受体结合的方法

    公开(公告)号：US06514710B1

    公开(公告)日：2003-02-04

    申请号：US09285783

    申请日：1999-04-05

    申请人： Terence R. Jones ,  David N. Haney ,  Janos Varga

    发明人： Terence R. Jones ,  David N. Haney ,  Janos Varga

    IPC分类号： A61K3812

    CPC分类号： C12N9/6462 ,  A61K38/00 ,  C07K7/54 ,  C12Y304/21073

    摘要： Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C&agr; carbon of the first amino acid and the C&agr; carbon of eleventh amino acid is between about 4 and 12 Ångstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.

    摘要翻译： 具有连接单元L连接的11个氨基酸的环肽化合物，使得第一氨基酸的Calpha碳与第十一氨基酸的Calpha碳之间的线性尺寸为约4至12埃单位; 可用于抑制uPA与uPAR受体的结合。 还公开了使用环肽化合物的方法和含有它们的组合物用于抑制癌性肿瘤的生长或转移。

    Cyclic peptides that bind to urokinase-type plasminogen activator receptor
    5.
    发明授权
    Cyclic peptides that bind to urokinase-type plasminogen activator receptor 失效
    结合尿激酶型纤溶酶原激活物受体的环肽

    公开(公告)号：US5942492A

    公开(公告)日：1999-08-24

    申请号：US747915

    申请日：1996-11-12

    申请人： Terence R. Jones ,  David N. Haney ,  Janos Varga

    发明人： Terence R. Jones ,  David N. Haney ,  Janos Varga

    IPC分类号： A61K38/00 ,  C07K7/54 ,  C12N9/72 ,  A61K38/12 ,  A61K38/08

    CPC分类号： C12N9/6462 ,  C07K7/54 ,  C12Y304/21073 ,  A61K38/00

    摘要： Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C.sup..alpha. carbon of the first amino acid and the C.sup..alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.

    摘要翻译： 具有由连接单元L连接的11个氨基酸的环状肽化合物，使得第一氨基酸的Cα碳与第十一氨基酸的Cα碳之间的直线尺寸为约4-12个氨基酸单元; 可用于抑制uPA与uPAR受体的结合。 还公开了使用环肽化合物的方法和含有它们的组合物用于抑制癌性肿瘤的生长或转移。

    Process for preparing dicalcium phosphate containing fertilizer
    6.
    发明授权
    Process for preparing dicalcium phosphate containing fertilizer 失效
    制备磷酸二钙肥料的方法

    公开(公告)号：US4177052A

    公开(公告)日：1979-12-04

    申请号：US902931

    申请日：1978-05-05

    申请人： Karl Entzmann ,  Gyorgy Kalman ,  Janos Varga ,  Miklos Vecsei ,  Gabor Jankovics ,  Laszlone Kozicz

    发明人： Karl Entzmann ,  Gyorgy Kalman ,  Janos Varga ,  Miklos Vecsei ,  Gabor Jankovics ,  Laszlone Kozicz

    IPC分类号： C05B3/00

    CPC分类号： C05B3/00

    摘要： There is disclosed a process for preparing fertilizers containing dicalcium phosphate from phosphates of mineral origin by mechanical activation. According to the invention grains larger than 5 mm of the sized or unsized starting phosphate compound of mineral origin are granulated up to a grain size of 1 to 4 mm, the granulated phosphate obtained is admixed with monocalcium phosphate and the phosphate crystals are activated by colliding the grains of the mixture at a speed of 70 to 120 m/sec.The fertilizer prepared according to the invention possesses numerous advantages over the known phosphate fertilizers from technological and applicational point of view as well.

    摘要翻译： 公开了一种通过机械活化从矿物来源的磷酸盐制备含磷酸二钙的肥料的方法。 根据本发明，将大于5mm的矿物来源的尺寸或未定型起始磷酸盐化合物的颗粒粒化至1至4mm的粒度，将得到的粒状磷酸盐与磷酸一钙混合，磷酸盐晶体通过碰撞而活化 混合物的颗粒以70至120m / sec的速度。 根据本发明制备的肥料在技术和应用的观点上具有优于已知磷酸盐肥料的许多优点。

    Contacting and drying of material in a spouted system
    7.
    发明授权
    Contacting and drying of material in a spouted system 失效
    在喷射系统中接触和干燥材料

    公开(公告)号：US4203228A

    公开(公告)日：1980-05-20

    申请号：US919300

    申请日：1978-06-26

    申请人： Emil Aradi ,  Tibor Blickle ,  Endre Monostori ,  Jeno Nemeth ,  Ivanne Pallai ,  Janos Varga

    发明人： Emil Aradi ,  Tibor Blickle ,  Endre Monostori ,  Jeno Nemeth ,  Ivanne Pallai ,  Janos Varga

    IPC分类号： F26B3/092 ,  F26B3/08 ,  F26B7/00

    CPC分类号： F26B3/0923

    摘要： An apparatus and a method for at least partially drying a first substantially granular material inclusive of a fluid, and mixing the first material with a second substantially granular material, includes a container, a conveyor disposed in the container, and an air supply for blowing air into the mixed first and second materials. The materials then become at least partially loosened, are dried by the air blown thereinto, are moved operatively at least partially upwards by the conveyor, and are then allowed to drop downwards within the container.

    摘要翻译： 一种用于至少部分地干燥包括流体在内的第一基本粒状材料并将第一材料与第二基本上颗粒状材料混合的装置和方法，包括容器，设置在容器中的传送器和用于吹送空气的空气源 进入混合的第一和第二材料。 材料然后变得至少部分松动，被吹入其中的空气干燥，由输送机至少部分向上移动，然后允许其在容器内向下落下。