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1.发明授权Methods of measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof 有权测量von Willebrand因子的ADAMTS13介导的体内裂解的方法及其用途公开(公告)号：US08415114B2
公开(公告)日：2013-04-09
申请号：US12630509
申请日：2009-12-03
申请人： Katalin Varadi , Hanspeter Rottensteiner , Peter Turecek , Hans-Peter Schwarz , Jutta Schreiner
发明人： Katalin Varadi , Hanspeter Rottensteiner , Peter Turecek , Hans-Peter Schwarz , Jutta Schreiner
IPC分类号： C12Q1/56
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
摘要翻译： 本发明一般涉及测量切割的血管性血友病因子（VWF）片段的方法。 更具体地，本发明涉及测量具有血小板反应蛋白1型基序，成员13（ADAMTS13）在体内切割VWF的解联蛋白和金属蛋白酶的能力的方法。 本发明还涉及使用表现出与人相似的ADAMTS13活性的各种动物模型的方法。 本发明还涉及测量哺乳动物，特别是人和人血浆中rVWF的切割产物的方法。
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2.发明申请METHODS OF MEASURING ADAMTS13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF 有权方法测量ADAMTS13-介导VIV WILLEBRAND因子的血液透析及其用途公开(公告)号：US20100143957A1
公开(公告)日：2010-06-10
申请号：US12630509
申请日：2009-12-03
申请人： Katalin Varadi , Hanspeter Rottensteiner , Peter Turecek , Hans-Peter Schwarz , Jutta Schreiner
发明人： Katalin Varadi , Hanspeter Rottensteiner , Peter Turecek , Hans-Peter Schwarz , Jutta Schreiner
IPC分类号： C12Q1/34
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
摘要翻译： 本发明一般涉及测量切割的血管性血友病因子（VWF）片段的方法。 更具体地，本发明涉及测量具有血小板反应蛋白1型基序，成员13（ADAMTS13）在体内切割VWF的解联蛋白和金属蛋白酶的能力的方法。 本发明还涉及使用表现出与人相似的ADAMTS13活性的各种动物模型的方法。 本发明还涉及测量哺乳动物，特别是人和人血浆中rVWF的切割产物的方法。
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