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    Methods of enhancing immune response using electroporation-assisted vaccination and boosting
    7.
    发明申请
    Methods of enhancing immune response using electroporation-assisted vaccination and boosting 审中-公开
    使用电穿孔辅助疫苗接种和加强增强免疫反应的方法

    公开(公告)号：US20100285040A1

    公开(公告)日：2010-11-11

    申请号：US11985871

    申请日：2007-11-16

    申请人： Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  Rune Kjeken ,  Dietmar Paul Rabussay ,  Feng Lin

    发明人： Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  Rune Kjeken ,  Dietmar Paul Rabussay ,  Feng Lin

    IPC分类号： A61K39/00 ,  A61K31/7088 ,  A61P37/04

    CPC分类号： A61K39/00 ,  A61K2039/545

    摘要： Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.

    摘要翻译： 公开了增强免疫应答的方法。 这样的方法涉及向不同组织施用疫苗组合物以引发增强的免疫应答。 增强的反应来自于在两个单独的患者组织中的接种和加强给药途径，例如，首先将皮下注射疫苗接种，然后在肌肉中施用加强免疫接种。 在每种情况下，引发和加强疫苗组合物的施用优选使用同时进行的抗原性电穿孔辅助递送来进行。

    Device and method for single-needle in vivo electroporation
    9.
    发明申请
    Device and method for single-needle in vivo electroporation 审中-公开
    单针体内电穿孔装置及方法

    公开(公告)号：US20070287950A1

    公开(公告)日：2007-12-13

    申请号：US11704591

    申请日：2007-02-09

    申请人： Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

    发明人： Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

    IPC分类号： A61N1/30

    CPC分类号： A61N1/327 ,  A61N1/30

    摘要： Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

    摘要翻译： 描述了用于在各种医疗应用中向体内组织施用分子的装置和方法，所述装置包括单个皮下注射针和至少两个间隔开的细长电极，其提供当针插入组织中时的能力，例如 皮肤或肌肉，以不均匀的电场脉冲组织，其足以引起沿着或靠近由针在其插入所述组织中时所制成的轨道的细胞的可逆定位。