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公开(公告)号：US20080108611A1
公开(公告)日：2008-05-08
申请号：US11621610
申请日：2007-01-10
申请人： Kathleen A. Battista , Gilles C. Bignan , Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Ronghui Lin , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
发明人： Kathleen A. Battista , Gilles C. Bignan , Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Ronghui Lin , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
IPC分类号： A61K31/519 , C07D495/04 , A61K31/5377 , A61P35/00 , A61P17/00 , A61P9/00 , C07D413/14
CPC分类号： C07D495/04
摘要： The present invention is directed to thienopyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译： 本发明涉及式（I）的噻吩并嘧啶化合物及其形式，其合成和用途，用于治疗，预防或改善慢性或急性蛋白激酶介导的疾病，病症或病症。
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公开(公告)号：US07579356B2
公开(公告)日：2009-08-25
申请号：US11401339
申请日：2006-04-10
申请人： Kathleen A. Battista , Gilles C. Bignan , Peter J. Connolly , Stuart Hayden , Sigmond G. Johnson , Ronghui Lin , Niranjan B. Pandey , Mark T. Powell
发明人： Kathleen A. Battista , Gilles C. Bignan , Peter J. Connolly , Stuart Hayden , Sigmond G. Johnson , Ronghui Lin , Niranjan B. Pandey , Mark T. Powell
IPC分类号： A01N43/54 , A61K31/515 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D495/16
摘要： The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
摘要翻译： 本发明涉及式（I）的新型硫代四氮杂苊烯化合物及其药学上可接受的形式，以及它们作为ATP-蛋白激酶相互作用抑制剂的合成和用途。
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3.发明授权公开(公告)号：US07427625B2
公开(公告)日：2008-09-23
申请号：US11672177
申请日：2007-02-07
申请人： Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Bharat Lagu , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
发明人： Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Bharat Lagu , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D495/06
摘要： The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译： 本发明涉及式（I）的取代的四氮杂苊烯-6-腈化合物及其形式，其用于治疗，预防或改善慢性或急性蛋白激酶介导的疾病，病症或病症的合成和用途。
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4.发明申请公开(公告)号：US20080300264A1
公开(公告)日：2008-12-04
申请号：US12191613
申请日：2008-08-14
申请人： Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Bharat Lagu , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
发明人： Peter J. Connolly , Stuart L. Emanuel , Stuart Hayden , Sigmond G. Johnson , Bharat Lagu , Steven A. Middleton , Niranjan B. Pandey , Mark T. Powell
IPC分类号： A61K31/519 , C07D495/16
CPC分类号： C07D495/06
摘要： The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译： 本发明涉及式（I）的取代的四氮杂苊烯-6-腈化合物及其形式，其用于治疗，预防或改善慢性或急性蛋白激酶介导的疾病，病症或病症的合成和用途。
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![Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors](/abs-image/US/2009/10/20/US07605154B2/abs.jpg.150x150.jpg)
5.发明授权公开(公告)号：US07605154B2
公开(公告)日：2009-10-20
申请号：US11498221
申请日：2006-08-02
申请人： Eva Binnun , Peter J. Connolly , Sigmond G. Johnson , Ronghui Lin , Steven A. Middleton , Sandra J. Moreno-Mazza , Niranjan B. Pandey , Steven K. Wetter
发明人： Eva Binnun , Peter J. Connolly , Sigmond G. Johnson , Ronghui Lin , Steven A. Middleton , Sandra J. Moreno-Mazza , Niranjan B. Pandey , Steven K. Wetter
IPC分类号： C07D401/10 , C07D417/10 , C07D413/10 , A61K31/55 , A61K31/541 , A61K31/5355 , A61K31/497 , A61K31/519 , A61P35/04 , A61P25/28 , A61P25/16
CPC分类号： C07D513/04
摘要： The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
摘要翻译： 本发明涉及式（I）的新型噻唑并嘧啶化合物或其形式或组合物及其作为ATP-蛋白激酶相互作用抑制剂的用途。
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公开(公告)号：US07659284B2
公开(公告)日：2010-02-09
申请号：US11226961
申请日：2005-09-15
IPC分类号： A61K31/4745 , C07D513/04
CPC分类号： C07D497/04 , C07D513/04
摘要： The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I):
摘要翻译： 本发明涉及新型噻唑并吡啶类，其药物组合物及其作为ATP-蛋白激酶相互作用抑制剂的用途。 噻唑并吡啶化合物具有下式（I）：
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7.发明授权Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphagiogenesis-dependent diseases 有权衍生自IV型胶原的模拟肽及其用于治疗血管生成和淋巴管生成依赖性疾病的用途公开(公告)号：US09056923B2
公开(公告)日：2015-06-16
申请号：US13992998
申请日：2011-12-12
申请人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
发明人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
摘要： Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.
摘要翻译： 公开了具有抗血管生成和抗肿瘤发生特性的模拟肽及其用于治疗癌症，眼部疾病如年龄相关性黄斑变性和其它血管发生依赖性疾病的方法。 更具体地，在内皮细胞增殖，迁移，粘附和管形成测定中表现出抗血管生成活性的活性非半胱氨酸类似物（模拟物），体外人乳腺癌细胞中的抗迁移活性，抗血管生成和抗 - 公开了乳腺癌异种移植模型体内的致瘤活性和年龄相关性黄斑变性模型。 目前公开的模拟肽还表现出抗淋巴管生成和直接抗致瘤性质。
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8.发明申请MIMETIC PEPTIDES DERIVED FROM COLLAGEN TYPE IV AND THEIR USE FOR TREATING ANGIOGENESIS- AND LYMPHAGIOGENESIS-DEPENDENT DISEASES 审中-公开从胶原IV型衍生的胶体蛋白及其用于治疗血管发生和淋巴细胞生成的疾病公开(公告)号：US20130316950A1
公开(公告)日：2013-11-28
申请号：US13992998
申请日：2011-12-12
申请人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
发明人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
IPC分类号： C07K14/78
摘要： Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.
摘要翻译： 公开了具有抗血管生成和抗肿瘤发生特性的模拟肽及其用于治疗癌症，眼部疾病如年龄相关性黄斑变性和其它血管发生依赖性疾病的方法。 更具体地，在内皮细胞增殖，迁移，粘附和管形成测定中表现出抗血管生成活性的活性非半胱氨酸类似物（模拟物），体外人乳腺癌细胞中的抗迁移活性，抗血管生成和抗 - 公开了乳腺癌异种移植模型体内的致瘤活性和年龄相关性黄斑变性模型。 目前公开的模拟肽还表现出抗淋巴管生成和直接抗致瘤性质。
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