公开(公告)号：US20070292475A1

公开(公告)日：2007-12-20

申请号：US11607382

申请日：2006-12-01

申请人： Kathleen Campbell ,  Pericles Calias ,  Gary Cook ,  Mary Ganley

发明人： Kathleen Campbell ,  Pericles Calias ,  Gary Cook ,  Mary Ganley

IPC分类号： A61K9/52 ,  A61P27/02

CPC分类号： A61K38/1866 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/1647 ,  A61K31/00

摘要： Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.

摘要翻译： 已经开发了用于治疗眼部疾病的生物活性剂的受控持续释放的制剂。 这些制剂基于由可生物降解的合成聚合物如聚（乳酸）（PLA），聚（乙醇酸）（PGA）及其共聚物的组合形成的固体微粒。 微粒的特征在于低爆发水平和有效的药物负载和持续释放。

公开(公告)号：US20070105782A1

公开(公告)日：2007-05-10

申请号：US11539975

申请日：2006-10-10

申请人： Kathleen Campbell

发明人： Kathleen Campbell

IPC分类号： A61K38/05 ,  A61K31/198 ,  A61K31/385 ,  A61K31/22

CPC分类号： A61K38/05 ,  A61K31/198 ,  A61K31/22 ,  A61K31/385 ,  A61K38/063

摘要： Pharmaceutical compositions and methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise and other toxic insults are provided. These methods comprise administering an effective amount of a protectant combination or composition comprising two or more protectants selected from the group of methionine protectant agents, N-acetylcysteine, carnitine, magnesium ions, lipoic acid, ebselen, glutathione, and glutathione ester. These protectant combinations can be administered prior to, simultaneously with, or subsequently to exposure to noise other toxic insults.

摘要翻译： 提供了已经暴露于有毒噪声水平和其他有毒污染的患者中预防或减少听力或平衡损失和耳细胞损伤的药物组合物和方法。 这些方法包括施用有效量的保护剂组合或组合物，其包含选自甲硫氨酸保护剂，N-乙酰半胱氨酸，肉碱，镁离子，硫辛酸，依布硒精，谷胱甘肽和谷胱甘肽酯的两种或更多种保护剂。 这些保护剂组合可以在暴露于其他有毒的侮辱之前，同时或之后施用。

公开(公告)号：US20060167101A1

公开(公告)日：2006-07-27

申请号：US11324744

申请日：2006-01-03

申请人： Kathleen Campbell

发明人： Kathleen Campbell

IPC分类号： A61K31/198 ,  A61K31/7076 ,  A61K31/22

CPC分类号： A61K31/7076 ,  A61K31/10 ,  A61K31/145 ,  A61K31/198 ,  A61K31/22 ,  A61K31/28 ,  A61K31/49 ,  A61K31/704 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to exposure to noise. Combinations of these time periods can also be employed.

公开(公告)号：US20050090551A1

公开(公告)日：2005-04-28

申请号：US10694436

申请日：2003-10-27

申请人： Kathleen Campbell

发明人： Kathleen Campbell

IPC分类号： A61K31/095 ,  A61K31/198 ,  A61K41/00

CPC分类号： A61K31/198 ,  A61K31/095 ,  A61K41/00 ,  A61K2300/00

摘要： Methods of preventing or reducing mucositis in patients who have been exposed to toxic levels of radiation or who are undergoing treatment with platinum-containing anti-tumor compounds are provided. The methods comprise administering an effective amount of a protective agent comprising methionine or a methionine-like moiety to said patient prior to, simultaneously with, or subsequently to exposure to radiation or administration of a platinum-containing anti-tumor compound. Combinations of these time periods can also be employed.

摘要翻译： 提供了在暴露于有毒水平的放射线或正在接受含铂抗肿瘤化合物治疗的患者中预防或减少粘膜炎的方法。 所述方法包括在暴露辐射或施用含铂抗肿瘤化合物之前，同时或之后向所述患者施用有效量的包含甲硫氨酸或甲硫氨酸样部分的保护剂。 也可以使用这些时间段的组合。