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公开(公告)号:US20090017019A1
公开(公告)日:2009-01-15
申请号:US12130844
申请日:2008-05-30
申请人: Kathleen M. Shields , Debra D. Pittman , Jeffrey L. Feldman , Robert Martinez , Christine Huard
发明人: Kathleen M. Shields , Debra D. Pittman , Jeffrey L. Feldman , Robert Martinez , Christine Huard
IPC分类号: A61K39/395 , C12N5/00 , A61K38/16 , A61K38/02 , A61K38/14 , A61K31/7052 , G01N33/68 , G01N33/53 , C12Q1/68 , A61P9/00 , A61P13/12
CPC分类号: C07K14/51 , Y10T436/143333
摘要: Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed.
摘要翻译: 公开了使用BMP-10的激动剂和拮抗剂调节心脏,肾脏和血管细胞功能和体内平衡的方法和组合物。 特别地,公开了用于治疗,预防和/或诊断与BMP-10相关的血管,肾,纤维化和心脏病症和/或病症的方法。 还公开了评估BMP-10调节剂的筛选方法,例如激动剂和拮抗剂。
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公开(公告)号:US07763441B2
公开(公告)日:2010-07-27
申请号:US11717426
申请日:2007-03-13
申请人: Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
发明人: Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
CPC分类号: C07K14/4702 , A61K38/1709 , C12N9/16
摘要: The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译: 本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。 还公开了包含或编码糖异生的调节剂的药物组合物。
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公开(公告)号:US20070270331A1
公开(公告)日:2007-11-22
申请号:US11717426
申请日:2007-03-13
申请人: Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
发明人: Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
IPC分类号: A61K38/02 , A61K31/7052 , A61P3/08 , C12N5/02
CPC分类号: C07K14/4702 , A61K38/1709 , C12N9/16
摘要: The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译: 本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。 还公开了包含或编码糖异生的调节剂的药物组合物。
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