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公开(公告)号：US20090017019A1
公开(公告)日：2009-01-15
申请号：US12130844
申请日：2008-05-30
申请人： Kathleen M. Shields , Debra D. Pittman , Jeffrey L. Feldman , Robert Martinez , Christine Huard
发明人： Kathleen M. Shields , Debra D. Pittman , Jeffrey L. Feldman , Robert Martinez , Christine Huard
IPC分类号： A61K39/395 , C12N5/00 , A61K38/16 , A61K38/02 , A61K38/14 , A61K31/7052 , G01N33/68 , G01N33/53 , C12Q1/68 , A61P9/00 , A61P13/12
CPC分类号： C07K14/51 , Y10T436/143333
摘要： Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed.
摘要翻译： 公开了使用BMP-10的激动剂和拮抗剂调节心脏，肾脏和血管细胞功能和体内平衡的方法和组合物。 特别地，公开了用于治疗，预防和/或诊断与BMP-10相关的血管，肾，纤维化和心脏病症和/或病症的方法。 还公开了评估BMP-10调节剂的筛选方法，例如激动剂和拮抗剂。
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公开(公告)号：US20100260767A1
公开(公告)日：2010-10-14
申请号：US12687981
申请日：2010-01-15
IPC分类号： A61K39/395 , C07K16/24 , A61P37/00 , A61P29/00
CPC分类号： C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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3.发明申请公开(公告)号：US20080200381A1
公开(公告)日：2008-08-21
申请号：US11881842
申请日：2007-07-30
申请人： Debra D. Pittman , Brian M. Clancy
发明人： Debra D. Pittman , Brian M. Clancy
CPC分类号： C12Q1/6883 , C12Q2600/158 , Y02A90/26
摘要： The invention provides methods and compositions for diagnostic assays for detecting bone and cartilage formation and therapeutic methods and compositions for treating disease and disorders related to bone and cartilage formation or resorption, such as osteoporosis and bone fractions. The invention also provides therapeutic methods for diseases related to bone or cartilage formation or resorption. Methods for identifying therapeutics for such diseases are also provided.
摘要翻译： 本发明提供了用于检测骨和软骨形成的诊断测定方法和组合物，以及用于治疗与骨和软骨形成或吸收相关的疾病和病症如骨质疏松症和骨骼部分的治疗方法和组合物。 本发明还提供了与骨或软骨形成或吸收相关的疾病的治疗方法。 还提供了用于鉴定这些疾病的治疗剂的方法。
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4.发明申请Expression of the cysteine protease legumain in vascular and inflammatory diseases 审中-公开半胱氨酸蛋白酶在血管和炎症疾病中的表达公开(公告)号：US20100158924A1
公开(公告)日：2010-06-24
申请号：US12700178
申请日：2010-02-04
申请人： Valerie Clerin , Heather H. Shih , Kathleen Shields , Jeffrey Feldman , Gustave T. Hebert , Debra D. Pittman , Nanhua Dan Deng
发明人： Valerie Clerin , Heather H. Shih , Kathleen Shields , Jeffrey Feldman , Gustave T. Hebert , Debra D. Pittman , Nanhua Dan Deng
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C07K16/00 , A61K31/7052 , A61K38/02 , C12Q1/37 , A61P9/00 , A61P29/00
CPC分类号： C12N9/6472 , A61K38/00 , C12Y304/22034 , G01N33/5091 , G01N2333/95 , G01N2800/32
摘要： The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.
摘要翻译： 本发明提供了与哺乳动物（例如，小鼠和人）legumain和新型legumain拼接变体ZB-1相关的分离和纯化的多核苷酸，多肽和抗体。 本发明还涉及这些分离和纯化的多核苷酸，多肽和抗体以及其他legumain和ZB-1激动剂和拮抗剂在调节legumain和/或ZB-1活性，表达和/或分泌中的用途 细胞或细胞群，例如单核细胞，巨噬细胞，泡沫细胞，血管内皮细胞，肾近端小管细胞，动脉内皮细胞，炎性细胞侵入血管内膜的部位和动脉的新内膜损伤区域。 本发明还提供legumain和ZB-1拮抗剂，例如对于legumain和ZB-1，legumain和ZB-1抑制性多肽的拮抗性小分子，抗体和抗体片段，以及legumain和ZB-1抑制性多核苷酸。 本发明还涉及用于诊断，预后，监测，治疗，改善和/或预防血管疾病/疾病和炎症性疾病/疾病的新颖方法。
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公开(公告)号：US07638604B2
公开(公告)日：2009-12-29
申请号：US10873972
申请日：2004-06-22
申请人： Jing Li , Xiang-Yang Tan , Kathleen N. Tomkinson , Debra D. Pittman , Geertruida M. Veldman , Lynette Fouser
发明人： Jing Li , Xiang-Yang Tan , Kathleen N. Tomkinson , Debra D. Pittman , Geertruida M. Veldman , Lynette Fouser
IPC分类号： C12P21/08 , A61K39/395
CPC分类号： C07K16/244 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).
摘要翻译： 公开了结合白介素22（IL-22），特别是人IL-22的抗体及其抗原结合片段及其在调节IL-22相关免疫应答中的用途。 本文公开的抗体可用于诊断，预防或治疗IL-22相关免疫病症，例如自身免疫性疾病（例如关节炎）。
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公开(公告)号：US07251568B2
公开(公告)日：2007-07-31
申请号：US10329056
申请日：2002-12-23
申请人： Debra D. Pittman , Brian M. Clancy
发明人： Debra D. Pittman , Brian M. Clancy
IPC分类号： G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/158 , Y02A90/26
摘要： The invention provides methods and compositions for diagnostic assays for detecting bone and cartilage formation and therapeutic methods and compositions for treating disease and disorders related to bone and cartilage formation or resorption, such as osteoporosis and bone fractions. The invention also provides therapeutic methods for diseases related to bone or cartilage formation or resorption. Methods for identifying therapeutics for such diseases are also provided.
摘要翻译： 本发明提供了用于检测骨和软骨形成的诊断测定方法和组合物，以及用于治疗与骨和软骨形成或吸收相关的疾病和病症如骨质疏松症和骨骼部分的治疗方法和组合物。 本发明还提供了与骨或软骨形成或吸收相关的疾病的治疗方法。 还提供了用于鉴定这些疾病的治疗剂的方法。
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公开(公告)号：US20110262390A1
公开(公告)日：2011-10-27
申请号：US13113552
申请日：2011-05-23
CPC分类号： C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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8.发明授权Method of treating psoriasis by administering IL-22 antibodies, or binding fragments thereof 失效通过施用IL-22抗体或其结合片段治疗牛皮癣的方法公开(公告)号：US07951372B1
公开(公告)日：2011-05-31
申请号：US11896363
申请日：2007-08-31
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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公开(公告)号：US07279559B2
公开(公告)日：2007-10-09
申请号：US10256977
申请日：2002-09-27
CPC分类号： C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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公开(公告)号：US06939545B2
公开(公告)日：2005-09-06
申请号：US10084298
申请日：2002-02-25
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54 , C07K16/24 , A61K39/395 , A61K39/00 , C07K14/555 , C07K16/00
CPC分类号： C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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