公开(公告)号：US20090017019A1

公开(公告)日：2009-01-15

申请号：US12130844

申请日：2008-05-30

申请人： Kathleen M. Shields ,  Debra D. Pittman ,  Jeffrey L. Feldman ,  Robert Martinez ,  Christine Huard

发明人： Kathleen M. Shields ,  Debra D. Pittman ,  Jeffrey L. Feldman ,  Robert Martinez ,  Christine Huard

IPC分类号： A61K39/395 ,  C12N5/00 ,  A61K38/16 ,  A61K38/02 ,  A61K38/14 ,  A61K31/7052 ,  G01N33/68 ,  G01N33/53 ,  C12Q1/68 ,  A61P9/00 ,  A61P13/12

CPC分类号： C07K14/51 ,  Y10T436/143333

摘要： Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed.

摘要翻译： 公开了使用BMP-10的激动剂和拮抗剂调节心脏，肾脏和血管细胞功能和体内平衡的方法和组合物。 特别地，公开了用于治疗，预防和/或诊断与BMP-10相关的血管，肾，纤维化和心脏病症和/或病症的方法。 还公开了评估BMP-10调节剂的筛选方法，例如激动剂和拮抗剂。

公开(公告)号：US20080306881A1

公开(公告)日：2008-12-11

申请号：US11962451

申请日：2007-12-21

申请人： Jeffrey L. Feldman

发明人： Jeffrey L. Feldman

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q40/06

摘要： A method and system are provided for creating an investment vehicle associated with a geographic region, the investment vehicle including a plurality of securities issued by companies. That method comprises forming a set of securities based on inclusion criteria, and categorizing the securities according to geographic region, where the geographic region of a security may be determined based at least in part on the presence of a headquarters location of the issuing company in the geographic region. A predetermined number of securities associated with the geographic region of the investment vehicle are selected from the set of securities for inclusion in the investment vehicle, and the resulting investment vehicle is made available for trading. According to other preferred aspects of the invention, the inclusion of a company in the investment vehicle may also be based in part on market capitalization, or on the number of employees within the geographic region, or based on whether the company is listed on a particular exchange.

摘要翻译： 提供了一种用于创建与地理区域相关联的投资工具的方法和系统，所述投资工具包括由公司发行的多个证券。 该方法包括基于包含标准形成一组证券，以及根据地理区域对证券进行分类，其中可以至少部分地基于在发行公司的总部位置的存在来确定证券的地理区域 地理区域。 从投资车辆的一组证券中选择与投资工具的地理区域相关联的预定数量的证券，并且所得到的投资工具可用于交易。 根据本发明的其他优选方面，在投资工具中包括公司也可能部分地基于市值，或者在地理区域内的雇员数量上，或者基于公司是否在特定的公司上市 交换。

公开(公告)号：US20090202474A1

公开(公告)日：2009-08-13

申请号：US12273945

申请日：2008-11-19

申请人： Priya CHOCKALINGAM ,  Manas K. MAJUMDAR ,  Debra D. PITTMAN ,  Julia BILLIARD ,  Edward Roland LAVALLIE ,  Jeffrey L. FELDMAN ,  Lisa COLLINS-RACIE ,  Vishnuvardhan DAESETY ,  Robert MORAN ,  Elisabeth A. MORRIS ,  Paul YAWORSKY

发明人： Priya CHOCKALINGAM ,  Manas K. MAJUMDAR ,  Debra D. PITTMAN ,  Julia BILLIARD ,  Edward Roland LAVALLIE ,  Jeffrey L. FELDMAN ,  Lisa COLLINS-RACIE ,  Vishnuvardhan DAESETY ,  Robert MORAN ,  Elisabeth A. MORRIS ,  Paul YAWORSKY

IPC分类号： A61K38/20 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/37 ,  C12Q1/00 ,  A61P29/00 ,  A61K38/16 ,  C07H21/00 ,  C12N15/63 ,  C12N5/08 ,  C12N5/06 ,  C12N1/19 ,  C12N1/21

CPC分类号： G01N33/566 ,  A61K38/00 ,  C07K14/775 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/065 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/108 ,  G01N2800/122 ,  G01N2800/24

摘要： Methods of screening for agents for treating inflammatory diseases are provided. The methods involve screening for agents that modulate the activity or expression of GPR64, which has been discovered herein to play a role in inflammatory diseases. Methods for treating an inflammatory disease, as well as methods of modulating the activity or expression of GPR64, methods of screening for an inflammatory disease in a subject, pharmaceutical compositions, a nucleic acid variant, and antibodies are also provided.

摘要翻译： 提供了用于治疗炎性疾病的药物的筛选方法。 该方法涉及筛选调节GPR64的活性或表达的试剂，其在本文中被发现在炎性疾病中发挥作用。 还提供了治疗炎性疾病的方法，以及调节GPR64的活性或表达的方法，筛选受试者炎性疾病的方法，药物组合物，核酸变体和抗体。