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    Dermal penetration enhancers and drug delivery systems involving same
    9.
    发明授权
    Dermal penetration enhancers and drug delivery systems involving same 有权
    皮肤渗透增强剂和涉及其的药物递送系统

    公开(公告)号：US06818226B2

    公开(公告)日：2004-11-16

    申请号：US09910780

    申请日：2001-07-24

    申请人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    发明人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    IPC分类号： A61K970

    CPC分类号： A61Q17/04 ,  A61K8/046 ,  A61K8/37 ,  A61K8/445 ,  A61K9/0014 ,  A61K9/12 ,  A61K9/122 ,  A61K47/14 ,  A61M35/003 ,  Y02A50/411 ,  Y10S514/947 ,  Y10S514/974

    摘要： A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.

    摘要翻译： 一种透皮药物递送系统，其包含至少一种生理活性剂或其前药和至少一种皮肤渗透促进剂; 其特征在于，所述皮肤渗透增强剂是安全的耐受皮肤的酯类防晒剂。非闭塞性，经皮或透皮药物递送系统，其包括：（i）有效量的至少一种生理活性剂或其前药;（ii） 至少一种非挥发性皮肤渗透增强剂; 和（iii）至少一种挥发性液体;其特征在于，当挥发性液体蒸发时，皮肤渗透增强剂适于将生理活性剂转运到包括人的动物的真皮表面或粘膜上，以形成储存器或 包含渗透促进剂和所述表面或膜内的生理活性剂或前药的混合物的贮存库;以及皮肤渗透增强剂对动物的真皮表面或粘膜具有低毒性并且被其表皮受体耐受。